Several transition series and IIB group metals were evaluated for effects on complement hemolysis of sheep red blood cells in vitro. Zinc and copper (10-4M) strongly inhibited complement activity by 83% and 66%, respectively. However, while manganese inhibited slightly (17%), neither cobalt nor cadmium had effect in this concentration range. Further results showed that zinc pre-treatment did not inactivate individual reaction components, and that zinc did not affect the membrane-lysis step. Rather, zinc exerted its effect only when added concomitantly with complement, suggesting that it interferes with the binding and/or activation steps necessary to form the complete complement complex.
|Original language||English (US)|
|Number of pages||5|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Jan 1974|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)