The effects of 13-cis-retinoic acid and beta-carotene on cellular immunity in humans

R. H. Prabhala, H. S. Garewal, M. J. Hicks, R. E. Sampliner, Ronald R Watson

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Deficiency of vitamin A and/or its precursors has been associated with increased cancer risk in animals and humans. Therapeutic trials of vitamin A and related compounds have demonstrated activity in several cancerous and precancerous conditions. The authors measured the effects of a retinoid, 13-cis-retinoic acid, and a carotenoid, beta-carotene, on the human immune system in vivo in conjunction with their use in ongoing clinical trials. Immune cell subpopulations were analyzed by quantifying the expression of markers using flow cytometric study. Both compounds produced significant effects on immune cell populations. 13-cis-Retinoic acid resulted in an increase in the percentage of peripheral blood lymphoid cells expressing surface markers for T-helper cells with only minimal effect on natural killer cell marker expression. In contrast, beta-carotene produced an increase in the percentage of cells expressing natural killer cell markers with smaller effect on T-helper markers. Modest increases in the percentage of cells expressing Ia antigen, transferrin, and interleukin-2 receptors were produced by both drugs. These results suggest that retinoids and carotenoids can produce major changes in immune cellular marker expression in vivo in humans at doses relevant to their potential clinical use.

Original languageEnglish (US)
Pages (from-to)1556-1560
Number of pages5
JournalCancer
Volume67
Issue number6
StatePublished - 1991

Fingerprint

Isotretinoin
beta Carotene
Cellular Immunity
Retinoids
Carotenoids
Natural Killer Cells
Precancerous Conditions
Vitamin A Deficiency
Interleukin-2 Receptors
Histocompatibility Antigens Class II
Transferrin
Helper-Inducer T-Lymphocytes
Vitamin A
Immune System
Blood Cells
Biomarkers
Clinical Trials
Lymphocytes
Pharmaceutical Preparations
Population

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Prabhala, R. H., Garewal, H. S., Hicks, M. J., Sampliner, R. E., & Watson, R. R. (1991). The effects of 13-cis-retinoic acid and beta-carotene on cellular immunity in humans. Cancer, 67(6), 1556-1560.

The effects of 13-cis-retinoic acid and beta-carotene on cellular immunity in humans. / Prabhala, R. H.; Garewal, H. S.; Hicks, M. J.; Sampliner, R. E.; Watson, Ronald R.

In: Cancer, Vol. 67, No. 6, 1991, p. 1556-1560.

Research output: Contribution to journalArticle

Prabhala, RH, Garewal, HS, Hicks, MJ, Sampliner, RE & Watson, RR 1991, 'The effects of 13-cis-retinoic acid and beta-carotene on cellular immunity in humans', Cancer, vol. 67, no. 6, pp. 1556-1560.
Prabhala RH, Garewal HS, Hicks MJ, Sampliner RE, Watson RR. The effects of 13-cis-retinoic acid and beta-carotene on cellular immunity in humans. Cancer. 1991;67(6):1556-1560.
Prabhala, R. H. ; Garewal, H. S. ; Hicks, M. J. ; Sampliner, R. E. ; Watson, Ronald R. / The effects of 13-cis-retinoic acid and beta-carotene on cellular immunity in humans. In: Cancer. 1991 ; Vol. 67, No. 6. pp. 1556-1560.
@article{23e7dca4472e43febc90c515f8ea8039,
title = "The effects of 13-cis-retinoic acid and beta-carotene on cellular immunity in humans",
abstract = "Deficiency of vitamin A and/or its precursors has been associated with increased cancer risk in animals and humans. Therapeutic trials of vitamin A and related compounds have demonstrated activity in several cancerous and precancerous conditions. The authors measured the effects of a retinoid, 13-cis-retinoic acid, and a carotenoid, beta-carotene, on the human immune system in vivo in conjunction with their use in ongoing clinical trials. Immune cell subpopulations were analyzed by quantifying the expression of markers using flow cytometric study. Both compounds produced significant effects on immune cell populations. 13-cis-Retinoic acid resulted in an increase in the percentage of peripheral blood lymphoid cells expressing surface markers for T-helper cells with only minimal effect on natural killer cell marker expression. In contrast, beta-carotene produced an increase in the percentage of cells expressing natural killer cell markers with smaller effect on T-helper markers. Modest increases in the percentage of cells expressing Ia antigen, transferrin, and interleukin-2 receptors were produced by both drugs. These results suggest that retinoids and carotenoids can produce major changes in immune cellular marker expression in vivo in humans at doses relevant to their potential clinical use.",
author = "Prabhala, {R. H.} and Garewal, {H. S.} and Hicks, {M. J.} and Sampliner, {R. E.} and Watson, {Ronald R}",
year = "1991",
language = "English (US)",
volume = "67",
pages = "1556--1560",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - The effects of 13-cis-retinoic acid and beta-carotene on cellular immunity in humans

AU - Prabhala, R. H.

AU - Garewal, H. S.

AU - Hicks, M. J.

AU - Sampliner, R. E.

AU - Watson, Ronald R

PY - 1991

Y1 - 1991

N2 - Deficiency of vitamin A and/or its precursors has been associated with increased cancer risk in animals and humans. Therapeutic trials of vitamin A and related compounds have demonstrated activity in several cancerous and precancerous conditions. The authors measured the effects of a retinoid, 13-cis-retinoic acid, and a carotenoid, beta-carotene, on the human immune system in vivo in conjunction with their use in ongoing clinical trials. Immune cell subpopulations were analyzed by quantifying the expression of markers using flow cytometric study. Both compounds produced significant effects on immune cell populations. 13-cis-Retinoic acid resulted in an increase in the percentage of peripheral blood lymphoid cells expressing surface markers for T-helper cells with only minimal effect on natural killer cell marker expression. In contrast, beta-carotene produced an increase in the percentage of cells expressing natural killer cell markers with smaller effect on T-helper markers. Modest increases in the percentage of cells expressing Ia antigen, transferrin, and interleukin-2 receptors were produced by both drugs. These results suggest that retinoids and carotenoids can produce major changes in immune cellular marker expression in vivo in humans at doses relevant to their potential clinical use.

AB - Deficiency of vitamin A and/or its precursors has been associated with increased cancer risk in animals and humans. Therapeutic trials of vitamin A and related compounds have demonstrated activity in several cancerous and precancerous conditions. The authors measured the effects of a retinoid, 13-cis-retinoic acid, and a carotenoid, beta-carotene, on the human immune system in vivo in conjunction with their use in ongoing clinical trials. Immune cell subpopulations were analyzed by quantifying the expression of markers using flow cytometric study. Both compounds produced significant effects on immune cell populations. 13-cis-Retinoic acid resulted in an increase in the percentage of peripheral blood lymphoid cells expressing surface markers for T-helper cells with only minimal effect on natural killer cell marker expression. In contrast, beta-carotene produced an increase in the percentage of cells expressing natural killer cell markers with smaller effect on T-helper markers. Modest increases in the percentage of cells expressing Ia antigen, transferrin, and interleukin-2 receptors were produced by both drugs. These results suggest that retinoids and carotenoids can produce major changes in immune cellular marker expression in vivo in humans at doses relevant to their potential clinical use.

UR - http://www.scopus.com/inward/record.url?scp=0025793897&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025793897&partnerID=8YFLogxK

M3 - Article

VL - 67

SP - 1556

EP - 1560

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 6

ER -