The effects of airway hyperresponsiveness, wheezing, and atopy on longitudinal pulmonary function in children: a 6-year follow-up study.

Duane L Sherrill, M. R. Sears, M. D. Lebowitz, M. D. Holdaway, C. J. Hewitt, E. M. Flannery, G. P. Herbison, P. A. Silva

Research output: Contribution to journalArticle

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Abstract

We examined growth of spirometric lung function in 696 children of European ancestry who were followed from ages 9 to 15 years and stratified according to their degree of responsiveness to methacholine inhalation challenge, atopic status, and respiratory symptoms. Subjects were participants in the longitudinal Multidisciplinary Health and Development Study in Dunedin, New Zealand. Forced expired volume in 1 second (FEV1), and vital capacity (VC) were measured at 9, 11, 13, and 15 years of age, concurrently with assessment of airway responsiveness determined by the concentration of methacholine causing a 20% fall in FEV1 (PC20 FEV1). Atopic status was assessed at age 13 by skin-prick testing to 11 allergens. In children demonstrating airway hyperresponsiveness, FEV1 increased with age at a slower rate, and the FEV1/VC ratio had a faster rate of decline through childhood, compared to non-responsive children. Subjects with positive skin tests to house dust mite and cat dander also had lower mean FEV1/VC ratios than the control group. Any reported wheezing was associated with slower growth of FEV1 and VC in males. We conclude that in New Zealand children with airway responsiveness and/or atopy to house dust mite or cat growth of spirometric lung function is impaired.

Original languageEnglish (US)
Pages (from-to)78-85
Number of pages8
JournalPediatric Pulmonology
Volume13
Issue number2
StatePublished - Jun 1992

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Vital Capacity
Respiratory Sounds
Pyroglyphidae
Lung
Methacholine Chloride
New Zealand
Cats
Growth
Dander
Skin Tests
Allergens
Inhalation
Control Groups
Skin
Health

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Sherrill, D. L., Sears, M. R., Lebowitz, M. D., Holdaway, M. D., Hewitt, C. J., Flannery, E. M., ... Silva, P. A. (1992). The effects of airway hyperresponsiveness, wheezing, and atopy on longitudinal pulmonary function in children: a 6-year follow-up study. Pediatric Pulmonology, 13(2), 78-85.

The effects of airway hyperresponsiveness, wheezing, and atopy on longitudinal pulmonary function in children : a 6-year follow-up study. / Sherrill, Duane L; Sears, M. R.; Lebowitz, M. D.; Holdaway, M. D.; Hewitt, C. J.; Flannery, E. M.; Herbison, G. P.; Silva, P. A.

In: Pediatric Pulmonology, Vol. 13, No. 2, 06.1992, p. 78-85.

Research output: Contribution to journalArticle

Sherrill, DL, Sears, MR, Lebowitz, MD, Holdaway, MD, Hewitt, CJ, Flannery, EM, Herbison, GP & Silva, PA 1992, 'The effects of airway hyperresponsiveness, wheezing, and atopy on longitudinal pulmonary function in children: a 6-year follow-up study.', Pediatric Pulmonology, vol. 13, no. 2, pp. 78-85.
Sherrill, Duane L ; Sears, M. R. ; Lebowitz, M. D. ; Holdaway, M. D. ; Hewitt, C. J. ; Flannery, E. M. ; Herbison, G. P. ; Silva, P. A. / The effects of airway hyperresponsiveness, wheezing, and atopy on longitudinal pulmonary function in children : a 6-year follow-up study. In: Pediatric Pulmonology. 1992 ; Vol. 13, No. 2. pp. 78-85.
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