The effects of improved hemodynamics on aortic dimensions in patients undergoing heart transplantation

David A. Bull, Leigh A Neumayer, Bryan J. Venerus, Charles W. Putnam, Luis Rosado, Pamela Lund, Kenneth E. McIntyre, Victor M. Bernhard, Jack G. Copeland, Gulshan K. Sethi, Glenn C. Hunter

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose: Retrospective studies have demonstrated an accelerated growth rate of abdominal aortic aneurysms in heart transplant patients. This prospective study was undertaken to define the relationship between cardiac hemodynamics and posttransplant aortic dilation. Methods: Sixty-eight patients undergoing heart (n = 60) or heart-lung (n = 8) transplantation were prospectively evaluated with abdominal ultrasonography before transplantation and annually after transplantation. Risk factors implicated in aneurysm growth, including age, indication for transplantation, immunosuppression, posttransplantation hypertension, and abdominal aortic dimension before transplantation were recorded. All patients underwent annual coronary artery catheterization and multiple gated acquisition scanning. Results: Thirty-seven patients (54%) had no change in aortic diameter after transplantation (pretransplantation and posttransplantation diameter = 1.8 ± 0.3 cm), over a mean follow-up period of 28 ± 14 months. In the remaining 31 (46%) patients, aortic diameter increased by 0.5 ± 0.6 cm over 31 ± 15 months (p < 0.05). Four (6%) of these 31 patients had abdominal aortic aneurysms (mean aortic diameter = 5.0 ± 0.8 cm). The mean increase in aortic diameter among these 4 patients was 1.8 ± 0.2 cm (annual rate of growth = 0.96 ± 0.3 cm/year). Patients experiencing an increase in aortic dimension after transplantation had significantly lower (p < 0.005) pretransplantation ejection fractions (17.1% ± 10.5% vs 28.6% ± 18.1%) and, as a consequence, significantly greater (p < 0.05) increases in their ejection fractions after transplantation compared with patients with stable aortic dimensions (42.7% ± 12.6% vs 31.8% ± 18.0%). Conclusions: Of 68 heart transplant patients prospectively evaluated, aortic diameter increased in 31 (46%); new aneurysms developed in four of these patients. Greater incremental increases in cardiac ejection fraction were significant correlates with aortic enlargement.

Original languageEnglish (US)
Pages (from-to)539-545
Number of pages7
JournalJournal of Vascular Surgery
Volume20
Issue number4
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Heart Transplantation
Hemodynamics
Transplantation
Abdominal Aortic Aneurysm
Aneurysm
Growth
Transplants
Catheterization
Immunosuppression
Dilatation
Ultrasonography
Coronary Vessels
Retrospective Studies
Prospective Studies
Hypertension
Lung

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

The effects of improved hemodynamics on aortic dimensions in patients undergoing heart transplantation. / Bull, David A.; Neumayer, Leigh A; Venerus, Bryan J.; Putnam, Charles W.; Rosado, Luis; Lund, Pamela; McIntyre, Kenneth E.; Bernhard, Victor M.; Copeland, Jack G.; Sethi, Gulshan K.; Hunter, Glenn C.

In: Journal of Vascular Surgery, Vol. 20, No. 4, 1994, p. 539-545.

Research output: Contribution to journalArticle

Bull, DA, Neumayer, LA, Venerus, BJ, Putnam, CW, Rosado, L, Lund, P, McIntyre, KE, Bernhard, VM, Copeland, JG, Sethi, GK & Hunter, GC 1994, 'The effects of improved hemodynamics on aortic dimensions in patients undergoing heart transplantation', Journal of Vascular Surgery, vol. 20, no. 4, pp. 539-545. https://doi.org/10.1016/0741-5214(94)90278-X
Bull, David A. ; Neumayer, Leigh A ; Venerus, Bryan J. ; Putnam, Charles W. ; Rosado, Luis ; Lund, Pamela ; McIntyre, Kenneth E. ; Bernhard, Victor M. ; Copeland, Jack G. ; Sethi, Gulshan K. ; Hunter, Glenn C. / The effects of improved hemodynamics on aortic dimensions in patients undergoing heart transplantation. In: Journal of Vascular Surgery. 1994 ; Vol. 20, No. 4. pp. 539-545.
@article{c179afb5cc5f4858bc766c90885f4658,
title = "The effects of improved hemodynamics on aortic dimensions in patients undergoing heart transplantation",
abstract = "Purpose: Retrospective studies have demonstrated an accelerated growth rate of abdominal aortic aneurysms in heart transplant patients. This prospective study was undertaken to define the relationship between cardiac hemodynamics and posttransplant aortic dilation. Methods: Sixty-eight patients undergoing heart (n = 60) or heart-lung (n = 8) transplantation were prospectively evaluated with abdominal ultrasonography before transplantation and annually after transplantation. Risk factors implicated in aneurysm growth, including age, indication for transplantation, immunosuppression, posttransplantation hypertension, and abdominal aortic dimension before transplantation were recorded. All patients underwent annual coronary artery catheterization and multiple gated acquisition scanning. Results: Thirty-seven patients (54{\%}) had no change in aortic diameter after transplantation (pretransplantation and posttransplantation diameter = 1.8 ± 0.3 cm), over a mean follow-up period of 28 ± 14 months. In the remaining 31 (46{\%}) patients, aortic diameter increased by 0.5 ± 0.6 cm over 31 ± 15 months (p < 0.05). Four (6{\%}) of these 31 patients had abdominal aortic aneurysms (mean aortic diameter = 5.0 ± 0.8 cm). The mean increase in aortic diameter among these 4 patients was 1.8 ± 0.2 cm (annual rate of growth = 0.96 ± 0.3 cm/year). Patients experiencing an increase in aortic dimension after transplantation had significantly lower (p < 0.005) pretransplantation ejection fractions (17.1{\%} ± 10.5{\%} vs 28.6{\%} ± 18.1{\%}) and, as a consequence, significantly greater (p < 0.05) increases in their ejection fractions after transplantation compared with patients with stable aortic dimensions (42.7{\%} ± 12.6{\%} vs 31.8{\%} ± 18.0{\%}). Conclusions: Of 68 heart transplant patients prospectively evaluated, aortic diameter increased in 31 (46{\%}); new aneurysms developed in four of these patients. Greater incremental increases in cardiac ejection fraction were significant correlates with aortic enlargement.",
author = "Bull, {David A.} and Neumayer, {Leigh A} and Venerus, {Bryan J.} and Putnam, {Charles W.} and Luis Rosado and Pamela Lund and McIntyre, {Kenneth E.} and Bernhard, {Victor M.} and Copeland, {Jack G.} and Sethi, {Gulshan K.} and Hunter, {Glenn C.}",
year = "1994",
doi = "10.1016/0741-5214(94)90278-X",
language = "English (US)",
volume = "20",
pages = "539--545",
journal = "Journal of Vascular Surgery",
issn = "0741-5214",
publisher = "Mosby Inc.",
number = "4",

}

TY - JOUR

T1 - The effects of improved hemodynamics on aortic dimensions in patients undergoing heart transplantation

AU - Bull, David A.

AU - Neumayer, Leigh A

AU - Venerus, Bryan J.

AU - Putnam, Charles W.

AU - Rosado, Luis

AU - Lund, Pamela

AU - McIntyre, Kenneth E.

AU - Bernhard, Victor M.

AU - Copeland, Jack G.

AU - Sethi, Gulshan K.

AU - Hunter, Glenn C.

PY - 1994

Y1 - 1994

N2 - Purpose: Retrospective studies have demonstrated an accelerated growth rate of abdominal aortic aneurysms in heart transplant patients. This prospective study was undertaken to define the relationship between cardiac hemodynamics and posttransplant aortic dilation. Methods: Sixty-eight patients undergoing heart (n = 60) or heart-lung (n = 8) transplantation were prospectively evaluated with abdominal ultrasonography before transplantation and annually after transplantation. Risk factors implicated in aneurysm growth, including age, indication for transplantation, immunosuppression, posttransplantation hypertension, and abdominal aortic dimension before transplantation were recorded. All patients underwent annual coronary artery catheterization and multiple gated acquisition scanning. Results: Thirty-seven patients (54%) had no change in aortic diameter after transplantation (pretransplantation and posttransplantation diameter = 1.8 ± 0.3 cm), over a mean follow-up period of 28 ± 14 months. In the remaining 31 (46%) patients, aortic diameter increased by 0.5 ± 0.6 cm over 31 ± 15 months (p < 0.05). Four (6%) of these 31 patients had abdominal aortic aneurysms (mean aortic diameter = 5.0 ± 0.8 cm). The mean increase in aortic diameter among these 4 patients was 1.8 ± 0.2 cm (annual rate of growth = 0.96 ± 0.3 cm/year). Patients experiencing an increase in aortic dimension after transplantation had significantly lower (p < 0.005) pretransplantation ejection fractions (17.1% ± 10.5% vs 28.6% ± 18.1%) and, as a consequence, significantly greater (p < 0.05) increases in their ejection fractions after transplantation compared with patients with stable aortic dimensions (42.7% ± 12.6% vs 31.8% ± 18.0%). Conclusions: Of 68 heart transplant patients prospectively evaluated, aortic diameter increased in 31 (46%); new aneurysms developed in four of these patients. Greater incremental increases in cardiac ejection fraction were significant correlates with aortic enlargement.

AB - Purpose: Retrospective studies have demonstrated an accelerated growth rate of abdominal aortic aneurysms in heart transplant patients. This prospective study was undertaken to define the relationship between cardiac hemodynamics and posttransplant aortic dilation. Methods: Sixty-eight patients undergoing heart (n = 60) or heart-lung (n = 8) transplantation were prospectively evaluated with abdominal ultrasonography before transplantation and annually after transplantation. Risk factors implicated in aneurysm growth, including age, indication for transplantation, immunosuppression, posttransplantation hypertension, and abdominal aortic dimension before transplantation were recorded. All patients underwent annual coronary artery catheterization and multiple gated acquisition scanning. Results: Thirty-seven patients (54%) had no change in aortic diameter after transplantation (pretransplantation and posttransplantation diameter = 1.8 ± 0.3 cm), over a mean follow-up period of 28 ± 14 months. In the remaining 31 (46%) patients, aortic diameter increased by 0.5 ± 0.6 cm over 31 ± 15 months (p < 0.05). Four (6%) of these 31 patients had abdominal aortic aneurysms (mean aortic diameter = 5.0 ± 0.8 cm). The mean increase in aortic diameter among these 4 patients was 1.8 ± 0.2 cm (annual rate of growth = 0.96 ± 0.3 cm/year). Patients experiencing an increase in aortic dimension after transplantation had significantly lower (p < 0.005) pretransplantation ejection fractions (17.1% ± 10.5% vs 28.6% ± 18.1%) and, as a consequence, significantly greater (p < 0.05) increases in their ejection fractions after transplantation compared with patients with stable aortic dimensions (42.7% ± 12.6% vs 31.8% ± 18.0%). Conclusions: Of 68 heart transplant patients prospectively evaluated, aortic diameter increased in 31 (46%); new aneurysms developed in four of these patients. Greater incremental increases in cardiac ejection fraction were significant correlates with aortic enlargement.

UR - http://www.scopus.com/inward/record.url?scp=0028149346&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028149346&partnerID=8YFLogxK

U2 - 10.1016/0741-5214(94)90278-X

DO - 10.1016/0741-5214(94)90278-X

M3 - Article

C2 - 7933255

AN - SCOPUS:0028149346

VL - 20

SP - 539

EP - 545

JO - Journal of Vascular Surgery

JF - Journal of Vascular Surgery

SN - 0741-5214

IS - 4

ER -