The effects of Legionella pneumophila toxin on oxidative processes and bacterial killing of human polymorphonuclear leukocytes

R. L. Friedman, J. E. Lochner, R. H. Bigley, B. H. Iglewski

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

The effect of Legionella pneumophila toxin on selected functions of human polymorphonuclear leukocytes was investigated. Amounts of L. pneumophila toxin that had no effect on leukocyte viability or phagocytosis significantly decreased hexose monophosphate shunt activity and O2 consumption during phagocytosis and bacterial iodination and killing in a dose-dependent fashion. The mechanism of action of this toxin appears to be unique among bacterial products thus far studied.

Original languageEnglish (US)
Pages (from-to)328-334
Number of pages7
JournalJournal of Infectious Diseases
Volume146
Issue number3
DOIs
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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