The effects of malnutrition on secretory and cellular immune processes.

Ronald R Watson, D. N. McMurray

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

About 15 million children under 5 years of age die each year due to suppressed immunity and the resulting increased infection. In severely malnourished children and animals some immune systems such as T-cell function, secretory IgA and complement are significantly suppressed. Other systems, such as the serum IgG or IgA, are normal or even elevated. Some of these changes are apparently caused by nutritional stress while others may be due to stimulation by increased incidence of infection and antigen load. On the other hand, marginal malnutrition stimulates increased phagocytosis and T-cell function with increased immunity to cancer but decreased resistance to certain microbial agents. The mechanisms of immune suppression by malnutrition, persistence of these effects after renutrition, and the effect of maternal malnutrition on newborn immunity are critically reviewed. Possible non-nutritional means of rapid immunological restoration of malnourished children are described.

Original languageEnglish (US)
Pages (from-to)113-159
Number of pages47
JournalCRC Critical Reviews in Food Science and Nutrition
Volume12
Issue number2
StatePublished - Dec 1979
Externally publishedYes

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T-cells
Malnutrition
malnutrition
Immunity
immunity
Immune system
Antigens
T-lymphocytes
Restoration
T-Lymphocytes
Secretory Immunoglobulin A
Animals
Infection
maternal effect
phagocytosis
Phagocytosis
infection
Immunoglobulin A
immune system
Immune System

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The effects of malnutrition on secretory and cellular immune processes. / Watson, Ronald R; McMurray, D. N.

In: CRC Critical Reviews in Food Science and Nutrition, Vol. 12, No. 2, 12.1979, p. 113-159.

Research output: Contribution to journalArticle

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