The emergence of genome-based drug repositioning

Yves A Lussier, James L. Chen

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

In a pair of papers in this issue of Science Translational Medicine, Butte et al. provide a concrete example of how reinterpreting and comparing genome-wide metrics allows us to effectively hypothesize which drugs from one disease-indication can be repurposed for another disease. The shift toward integrative genome-wide computational approaches has precedence in insightful scalar theories of biological information. Here, we discuss how this recent work in drug repurposing adheres to and takes advantage of the concepts surrounding this information paradigm.

Original languageEnglish (US)
Article number96ps35
JournalScience Translational Medicine
Volume3
Issue number96
DOIs
StatePublished - Aug 17 2011
Externally publishedYes

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Drug Repositioning
Genome
Information Theory
Translational Medical Research
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The emergence of genome-based drug repositioning. / Lussier, Yves A; Chen, James L.

In: Science Translational Medicine, Vol. 3, No. 96, 96ps35, 17.08.2011.

Research output: Contribution to journalArticle

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