The endothelial glycocalyx: Emerging concepts in pulmonary edema and acute lung injury

Stephen R. Collins, Randal S. Blank, Lindy S. Deatherage, Randal O. Dull

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The endothelial glycocalyx is a dynamic layer of macromolecules at the luminal surface of vascular endothelium that is involved in fluid homeostasis and regulation. Its role in vascular permeability and edema formation is emerging but is still not well understood. In this special article, we highlight key concepts of endothelial dysfunction with regards to the glycocalyx and provide new insights into the glycocalyx as a mediator of processes central to the development of pulmonary edema and lung injury.

Original languageEnglish (US)
Pages (from-to)664-674
Number of pages11
JournalAnesthesia and analgesia
Volume117
Issue number3
DOIs
StatePublished - Sep 1 2013
Externally publishedYes

Fingerprint

Glycocalyx
Acute Lung Injury
Pulmonary Edema
Lung Injury
Vascular Endothelium
Capillary Permeability
Edema
Homeostasis

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

The endothelial glycocalyx : Emerging concepts in pulmonary edema and acute lung injury. / Collins, Stephen R.; Blank, Randal S.; Deatherage, Lindy S.; Dull, Randal O.

In: Anesthesia and analgesia, Vol. 117, No. 3, 01.09.2013, p. 664-674.

Research output: Contribution to journalArticle

Collins, Stephen R. ; Blank, Randal S. ; Deatherage, Lindy S. ; Dull, Randal O. / The endothelial glycocalyx : Emerging concepts in pulmonary edema and acute lung injury. In: Anesthesia and analgesia. 2013 ; Vol. 117, No. 3. pp. 664-674.
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