The endothelial glycocalyx: Emerging concepts in pulmonary edema and acute lung injury

Stephen R. Collins, Randal S. Blank, Lindy S. Deatherage, Randal O. Dull

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

The endothelial glycocalyx is a dynamic layer of macromolecules at the luminal surface of vascular endothelium that is involved in fluid homeostasis and regulation. Its role in vascular permeability and edema formation is emerging but is still not well understood. In this special article, we highlight key concepts of endothelial dysfunction with regards to the glycocalyx and provide new insights into the glycocalyx as a mediator of processes central to the development of pulmonary edema and lung injury.

Original languageEnglish (US)
Pages (from-to)664-674
Number of pages11
JournalAnesthesia and analgesia
Volume117
Issue number3
DOIs
StatePublished - Sep 2013
Externally publishedYes

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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