The envelope glycoprotein ectodomains determine the efficiency of CD4+ T lymphocyte depletion in simian-human immunodeficiency virus-infected macaques

Gunilla B. Karlsson, Matilda Halloran, Dominik Schenten, Juliette Lee, Paul Racz, Klara Tenner-Racz, Judith Manola, Rebecca Gelman, Bijan Etemad-Moghadam, Elizabeth Desjardins, Richard Wyatt, Norma P. Gerard, Luisa Marcon, David Margolin, John Fanton, Michael K. Axthelm, Norman L. Letvin, Joseph Sodroski

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

CD4+ T lymphocyte depletion in human immunodeficiency virus type 1 (HIV-1)-infected humans underlies the development of acquired immune deficiency syndrome. Using a model in which rhesus macaques were infected with chimeric simian-human immunodeficiency viruses (SHIVs), we show that both the level of viremia and the structure of the HIV-1 envelope glycoprotein ectodomains individually contributed to the efficiency with which CD4+ T lymphocytes were depleted. The envelope glycoproteins of recombinant SHIVs that efficiently caused loss of CD4+ T lymphocytes exhibited increased chemokine receptor binding and membrane-fusing capacity compared with those of less pathogenic viruses. These studies identify the HIV-1 envelope glycoprotein ectodomains as determinants of CD4+ T lymphocyte loss in vivo and provide a foundation for studying pathogenic mechanisms.

Original languageEnglish (US)
Pages (from-to)1159-1171
Number of pages13
JournalJournal of Experimental Medicine
Volume188
Issue number6
DOIs
StatePublished - Sep 21 1998
Externally publishedYes

Fingerprint

Lymphocyte Depletion
Simian Immunodeficiency Virus
Macaca
Glycoproteins
HIV
T-Lymphocytes
HIV-1
Chemokine Receptors
Viremia
Human Development
Macaca mulatta
Acquired Immunodeficiency Syndrome
Viruses
Membranes

Keywords

  • CD4 T lymphocyte depletion
  • Envelope glycoprotein
  • Pathogenesis
  • Rhesus macaques
  • Simian-human immunodeficiency virus

ASJC Scopus subject areas

  • Immunology

Cite this

The envelope glycoprotein ectodomains determine the efficiency of CD4+ T lymphocyte depletion in simian-human immunodeficiency virus-infected macaques. / Karlsson, Gunilla B.; Halloran, Matilda; Schenten, Dominik; Lee, Juliette; Racz, Paul; Tenner-Racz, Klara; Manola, Judith; Gelman, Rebecca; Etemad-Moghadam, Bijan; Desjardins, Elizabeth; Wyatt, Richard; Gerard, Norma P.; Marcon, Luisa; Margolin, David; Fanton, John; Axthelm, Michael K.; Letvin, Norman L.; Sodroski, Joseph.

In: Journal of Experimental Medicine, Vol. 188, No. 6, 21.09.1998, p. 1159-1171.

Research output: Contribution to journalArticle

Karlsson, GB, Halloran, M, Schenten, D, Lee, J, Racz, P, Tenner-Racz, K, Manola, J, Gelman, R, Etemad-Moghadam, B, Desjardins, E, Wyatt, R, Gerard, NP, Marcon, L, Margolin, D, Fanton, J, Axthelm, MK, Letvin, NL & Sodroski, J 1998, 'The envelope glycoprotein ectodomains determine the efficiency of CD4+ T lymphocyte depletion in simian-human immunodeficiency virus-infected macaques', Journal of Experimental Medicine, vol. 188, no. 6, pp. 1159-1171. https://doi.org/10.1084/jem.188.6.1159
Karlsson, Gunilla B. ; Halloran, Matilda ; Schenten, Dominik ; Lee, Juliette ; Racz, Paul ; Tenner-Racz, Klara ; Manola, Judith ; Gelman, Rebecca ; Etemad-Moghadam, Bijan ; Desjardins, Elizabeth ; Wyatt, Richard ; Gerard, Norma P. ; Marcon, Luisa ; Margolin, David ; Fanton, John ; Axthelm, Michael K. ; Letvin, Norman L. ; Sodroski, Joseph. / The envelope glycoprotein ectodomains determine the efficiency of CD4+ T lymphocyte depletion in simian-human immunodeficiency virus-infected macaques. In: Journal of Experimental Medicine. 1998 ; Vol. 188, No. 6. pp. 1159-1171.
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