The evolutionary origin of an altruistic gene

Aurora M. Nedelcu, Richard E Michod

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Although the conditions favoring altruism are being increasingly understood, the evolutionary origins of the genetic basis for this behavior remain elusive. Here, we show that reproductive altruism (i.e., a sterile soma) in the multicellular green alga, Volvox carteri, evolved via the co-option of a life-history gene whose expression in the unicellular ancestor was conditioned on an environmental cue (as an adaptive strategy to enhance survival at an immediate cost to reproduction) through shifting its expression from a temporal (environmentally induced) into a spatial (developmental) context. The gene belongs to a diverged and structurally heterogeneous multigene family sharing a SAND-like domain (a DNA-binding module involved in gene transcription regulation). To our knowledge, this is the first example of a social gene specifically associated with reproductive altruism, whose origin can be traced back to a solitary ancestor. These findings complement recent proposals that the differentiation of sterile castes in social insects involved the co-option of regulatory networks that control sequential shifts between phases in the life cycle of solitary insects.

Original languageEnglish (US)
Pages (from-to)1460-1464
Number of pages5
JournalMolecular Biology and Evolution
Volume23
Issue number8
DOIs
StatePublished - Aug 2006

Fingerprint

Altruism
altruism
Genes
ancestry
Insects
gene
Volvox
Carterus
environmental cue
Chlorophyta
social insect
DNA-binding domains
genes
caste
social insects
Carisoprodol
Transcription
Algae
Multigene Family
Life Cycle Stages

Keywords

  • Chlamydomonas reinhardtii
  • regA
  • Reproductive altruism
  • SAND
  • Sociality
  • Volvox carteri

ASJC Scopus subject areas

  • Genetics
  • Biochemistry
  • Genetics(clinical)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Ecology, Evolution, Behavior and Systematics
  • Agricultural and Biological Sciences (miscellaneous)
  • Molecular Biology

Cite this

The evolutionary origin of an altruistic gene. / Nedelcu, Aurora M.; Michod, Richard E.

In: Molecular Biology and Evolution, Vol. 23, No. 8, 08.2006, p. 1460-1464.

Research output: Contribution to journalArticle

Nedelcu, Aurora M. ; Michod, Richard E. / The evolutionary origin of an altruistic gene. In: Molecular Biology and Evolution. 2006 ; Vol. 23, No. 8. pp. 1460-1464.
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