The excitatory response of in vitro hippocampal pyramidal cells to normorphine and methionine-enkephalin may be mediated by different receptor populations

E. D. French, W. Zieglgänsberger

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

As shown previously, opiate agonists increase the excitability of hippocampal pyramidal cells in a naloxone-reversible manner. In the present study, the degree of excitability was measured by population spike size recorded from hippocampus slices (CA1) obtained from naive or chronically morphinized rats. Cross tolerance could not be demonstrated to occur between met-enkephalin and normorphine in hippocampal cells made tolerant to morphine: the potent stimulatory effect of metenkephaline remains when applied to hippocampal slices removed from chronically morphinized rats, whereas normorphine was no longer effective. When these slices are washed or exposed to naloxone a diminution of the population spike occurs. These results suggest that while both opiate agonists increase neuronal excitability of hippocampal pyramidal cells, this effect is most likely mediated via different receptor populations.

Original languageEnglish (US)
Pages (from-to)238-244
Number of pages7
JournalExperimental Brain Research
Volume48
Issue number2
DOIs
StatePublished - Nov 1 1982

Keywords

  • Hippocampus slice
  • Multiple receptors
  • Opiate agonists

ASJC Scopus subject areas

  • Neuroscience(all)

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