The genetic prehistory of the Andean highlands 7,000 Years BP though European contact

John Lindo, Randall Haas, Courtney Hofman, Mario Apata, Mauricio Moraga, Ricardo Verdugo, James T. Watson, Carlos Viviano Llave, David Witonsky, Enrique Vargas Pacheco, Mercedes Villena, Rudy Soria, Cynthia Beall, Christina Warinner, John Novembre, Mark Aldenderfer, Anna Di Rienzo

Research output: Contribution to journalArticlepeer-review

Abstract

The peopling of the Andean highlands above 2500m in elevation was a complex process that included cultural, biological and genetic adaptations. Here we present a time series of ancient whole genomes from the Andes of Peru, dating back to 7,000 calendar years before present (BP), and compare them to 64 new genome-wide genetic variation datasets from both high and lowland populations. We infer three significant features: a split between low and high elevation populations that occurred between 9200-8200 BP; a population collapse after European contact that is significantly more severe in South American lowlanders than in highland populations; and evidence for positive selection at genetic loci related to starch digestion and plausibly pathogen resistance after European contact. Importantly, we do not find selective sweep signals related to known components of the human hypoxia response, which may suggest more complex modes of genetic adaptation to high altitude. One Sentence Summary Ancient DNA from the Andes reveals a complex picture of human adaptation from early settlement to the colonial period.

Original languageEnglish (US)
JournalUnknown Journal
DOIs
StatePublished - Jul 31 2018

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint Dive into the research topics of 'The genetic prehistory of the Andean highlands 7,000 Years BP though European contact'. Together they form a unique fingerprint.

Cite this