The glomerular complement receptor in immunologically mediated renal glomerular injury

M. C. Gelfand, M. L. Shin, Raymond B Nagle, I. Green, M. M. Frank

Research output: Contribution to journalArticle

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Abstract

The authors examined 25 renal biopsy specimens to determine whether there is a relation between immunologically mediated renal disease and the activity of complement receptors that selectively bind antigen antibody complexes containing activated third component of complement (C3b). These receptors have been termed glomerular complement receptors. Renal lesions associated with in vivo deposition of C3 were associated with a loss of receptor sites as demonstrated by reduced or absent in vitro binding of C3b coated test reagents by glomerular complement receptor. These findings suggest that binding of complement containing immune complexes to glomerular complement receptors in human subjects may participate in the immunopathologic processes of certain immune complex mediated renal diseases.

Original languageEnglish (US)
Pages (from-to)10-14
Number of pages5
JournalNew England Journal of Medicine
Volume295
Issue number1
StatePublished - 1976
Externally publishedYes

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Complement Receptors
Antigen-Antibody Complex
Kidney
Wounds and Injuries
Complement C3b
Biopsy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The glomerular complement receptor in immunologically mediated renal glomerular injury. / Gelfand, M. C.; Shin, M. L.; Nagle, Raymond B; Green, I.; Frank, M. M.

In: New England Journal of Medicine, Vol. 295, No. 1, 1976, p. 10-14.

Research output: Contribution to journalArticle

Gelfand, M. C. ; Shin, M. L. ; Nagle, Raymond B ; Green, I. ; Frank, M. M. / The glomerular complement receptor in immunologically mediated renal glomerular injury. In: New England Journal of Medicine. 1976 ; Vol. 295, No. 1. pp. 10-14.
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