The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity

Erik R. Hanschen, Tara N. Marriage, Patrick J. Ferris, Takashi Hamaji, Atsushi Toyoda, Asao Fujiyama, Rafik Neme, Hideki Noguchi, Yohei Minakuchi, Masahiro Suzuki, Hiroko Kawai-Toyooka, David R. Smith, Halle Sparks, Jaden Anderson, Robert Bakarić, Victor Luria, Amir Karger, Marc W. Kirschner, Pierre M. Durand, Richard E Michod & 2 others Hisayoshi Nozaki, Bradley J S C Olson

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The transition to multicellularity has occurred numerous times in all domains of life, yet its initial steps are poorly understood. The volvocine green algae are a tractable system for understanding the genetic basis of multicellularity including the initial formation of cooperative cell groups. Here we report the genome sequence of the undifferentiated colonial alga, Gonium pectorale, where group formation evolved by co-option of the retinoblastoma cell cycle regulatory pathway. Significantly, expression of the Gonium retinoblastoma cell cycle regulator in unicellular Chlamydomonas causes it to become colonial. The presence of these changes in undifferentiated Gonium indicates extensive group-level adaptation during the initial step in the evolution of multicellularity. These results emphasize an early and formative step in the evolution of multicellularity, the evolution of cell cycle regulation, one that may shed light on the evolutionary history of other multicellular innovations and evolutionary transitions.

Original languageEnglish (US)
Article number11370
JournalNature Communications
Volume7
DOIs
StatePublished - Apr 22 2016

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genome
Cell Cycle
Retinoblastoma
Genes
Cells
Genome
algae
cycles
Algae
Chlamydomonas
Chlorophyta
regulators
History
histories
Innovation
causes
cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Physics and Astronomy(all)

Cite this

Hanschen, E. R., Marriage, T. N., Ferris, P. J., Hamaji, T., Toyoda, A., Fujiyama, A., ... Olson, B. J. S. C. (2016). The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity. Nature Communications, 7, [11370]. https://doi.org/10.1038/ncomms11370

The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity. / Hanschen, Erik R.; Marriage, Tara N.; Ferris, Patrick J.; Hamaji, Takashi; Toyoda, Atsushi; Fujiyama, Asao; Neme, Rafik; Noguchi, Hideki; Minakuchi, Yohei; Suzuki, Masahiro; Kawai-Toyooka, Hiroko; Smith, David R.; Sparks, Halle; Anderson, Jaden; Bakarić, Robert; Luria, Victor; Karger, Amir; Kirschner, Marc W.; Durand, Pierre M.; Michod, Richard E; Nozaki, Hisayoshi; Olson, Bradley J S C.

In: Nature Communications, Vol. 7, 11370, 22.04.2016.

Research output: Contribution to journalArticle

Hanschen, ER, Marriage, TN, Ferris, PJ, Hamaji, T, Toyoda, A, Fujiyama, A, Neme, R, Noguchi, H, Minakuchi, Y, Suzuki, M, Kawai-Toyooka, H, Smith, DR, Sparks, H, Anderson, J, Bakarić, R, Luria, V, Karger, A, Kirschner, MW, Durand, PM, Michod, RE, Nozaki, H & Olson, BJSC 2016, 'The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity', Nature Communications, vol. 7, 11370. https://doi.org/10.1038/ncomms11370
Hanschen, Erik R. ; Marriage, Tara N. ; Ferris, Patrick J. ; Hamaji, Takashi ; Toyoda, Atsushi ; Fujiyama, Asao ; Neme, Rafik ; Noguchi, Hideki ; Minakuchi, Yohei ; Suzuki, Masahiro ; Kawai-Toyooka, Hiroko ; Smith, David R. ; Sparks, Halle ; Anderson, Jaden ; Bakarić, Robert ; Luria, Victor ; Karger, Amir ; Kirschner, Marc W. ; Durand, Pierre M. ; Michod, Richard E ; Nozaki, Hisayoshi ; Olson, Bradley J S C. / The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity. In: Nature Communications. 2016 ; Vol. 7.
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