The human Y chromosome homologue of XG: Transcription of a naturally truncated gene

Polly A. Weller, Ricky Critcher, Peter N. Goodfellow, James German, Nathan A. Ellis

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

The XG blood group gene spans PABX1, the pseudoautosomal boundary on the X chromosome. The first three exons are pseudoautosomal and the remaining seven are X-speciflc. On the V chromosome SRY and RPS4Y are located In Y-specific sequences within 70 kb of the boundary. Transcription from the XG promoter on the Y chromosome has been detected by cDNA cloning and PCR-based methods. Splicing of the pseudoautosomal exon 3 of XG occurs to multiple sites In Y-speciflc sequences. Transcripts detected include antisense SRY sequences and XG̃RPS4Y hybrid transcripts. The heterogeneity and low abundance of transcripts as well as the lack of maintenance of the XG open reading frame in all but one transcript argue against a specific Y-chromosome gene product. An expressed pseudogene of XG, XGPY, has been mapped to interval Yqll.21. XGPY is transcribed and subject to alternative splicing. Sequence comparison suggests that XGPY orlginated from XG by a gene duplication event in the primate lineage.

Original languageEnglish (US)
Pages (from-to)859-868
Number of pages10
JournalHuman molecular genetics
Volume4
Issue number5
DOIs
StatePublished - May 1 1995
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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