The human Y chromosome homologue of XG

Transcription of a naturally truncated gene

Polly A. Weller, Ricky Critcher, Peter N. Goodfellow, James German, Nathan Ellis

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The XG blood group gene spans PABX1, the pseudoautosomal boundary on the X chromosome. The first three exons are pseudoautosomal and the remaining seven are X-speciflc. On the V chromosome SRY and RPS4Y are located In Y-specific sequences within 70 kb of the boundary. Transcription from the XG promoter on the Y chromosome has been detected by cDNA cloning and PCR-based methods. Splicing of the pseudoautosomal exon 3 of XG occurs to multiple sites In Y-speciflc sequences. Transcripts detected include antisense SRY sequences and XG̃RPS4Y hybrid transcripts. The heterogeneity and low abundance of transcripts as well as the lack of maintenance of the XG open reading frame in all but one transcript argue against a specific Y-chromosome gene product. An expressed pseudogene of XG, XGPY, has been mapped to interval Yqll.21. XGPY is transcribed and subject to alternative splicing. Sequence comparison suggests that XGPY orlginated from XG by a gene duplication event in the primate lineage.

Original languageEnglish (US)
Pages (from-to)859-868
Number of pages10
JournalHuman Molecular Genetics
Volume4
Issue number5
DOIs
StatePublished - May 1995
Externally publishedYes

Fingerprint

Chromosomes, Human, Y
Transcription
Chromosomes
Chromosome
Exons
Genes
Y-Linked Genes
Gene
Pseudogenes
Gene Duplication
Y Chromosome
Alternative Splicing
X Chromosome
Blood Group Antigens
Primates
Open Reading Frames
Organism Cloning
Complementary DNA
CDNA Cloning
Maintenance

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Public Health, Environmental and Occupational Health
  • Molecular Biology
  • Genetics(clinical)
  • Genetics

Cite this

The human Y chromosome homologue of XG : Transcription of a naturally truncated gene. / Weller, Polly A.; Critcher, Ricky; Goodfellow, Peter N.; German, James; Ellis, Nathan.

In: Human Molecular Genetics, Vol. 4, No. 5, 05.1995, p. 859-868.

Research output: Contribution to journalArticle

Weller, Polly A. ; Critcher, Ricky ; Goodfellow, Peter N. ; German, James ; Ellis, Nathan. / The human Y chromosome homologue of XG : Transcription of a naturally truncated gene. In: Human Molecular Genetics. 1995 ; Vol. 4, No. 5. pp. 859-868.
@article{7070544ee74043229abf033d77248f66,
title = "The human Y chromosome homologue of XG: Transcription of a naturally truncated gene",
abstract = "The XG blood group gene spans PABX1, the pseudoautosomal boundary on the X chromosome. The first three exons are pseudoautosomal and the remaining seven are X-speciflc. On the V chromosome SRY and RPS4Y are located In Y-specific sequences within 70 kb of the boundary. Transcription from the XG promoter on the Y chromosome has been detected by cDNA cloning and PCR-based methods. Splicing of the pseudoautosomal exon 3 of XG occurs to multiple sites In Y-speciflc sequences. Transcripts detected include antisense SRY sequences and XG̃RPS4Y hybrid transcripts. The heterogeneity and low abundance of transcripts as well as the lack of maintenance of the XG open reading frame in all but one transcript argue against a specific Y-chromosome gene product. An expressed pseudogene of XG, XGPY, has been mapped to interval Yqll.21. XGPY is transcribed and subject to alternative splicing. Sequence comparison suggests that XGPY orlginated from XG by a gene duplication event in the primate lineage.",
author = "Weller, {Polly A.} and Ricky Critcher and Goodfellow, {Peter N.} and James German and Nathan Ellis",
year = "1995",
month = "5",
doi = "10.1093/hmg/4.5.859",
language = "English (US)",
volume = "4",
pages = "859--868",
journal = "Human Molecular Genetics",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "5",

}

TY - JOUR

T1 - The human Y chromosome homologue of XG

T2 - Transcription of a naturally truncated gene

AU - Weller, Polly A.

AU - Critcher, Ricky

AU - Goodfellow, Peter N.

AU - German, James

AU - Ellis, Nathan

PY - 1995/5

Y1 - 1995/5

N2 - The XG blood group gene spans PABX1, the pseudoautosomal boundary on the X chromosome. The first three exons are pseudoautosomal and the remaining seven are X-speciflc. On the V chromosome SRY and RPS4Y are located In Y-specific sequences within 70 kb of the boundary. Transcription from the XG promoter on the Y chromosome has been detected by cDNA cloning and PCR-based methods. Splicing of the pseudoautosomal exon 3 of XG occurs to multiple sites In Y-speciflc sequences. Transcripts detected include antisense SRY sequences and XG̃RPS4Y hybrid transcripts. The heterogeneity and low abundance of transcripts as well as the lack of maintenance of the XG open reading frame in all but one transcript argue against a specific Y-chromosome gene product. An expressed pseudogene of XG, XGPY, has been mapped to interval Yqll.21. XGPY is transcribed and subject to alternative splicing. Sequence comparison suggests that XGPY orlginated from XG by a gene duplication event in the primate lineage.

AB - The XG blood group gene spans PABX1, the pseudoautosomal boundary on the X chromosome. The first three exons are pseudoautosomal and the remaining seven are X-speciflc. On the V chromosome SRY and RPS4Y are located In Y-specific sequences within 70 kb of the boundary. Transcription from the XG promoter on the Y chromosome has been detected by cDNA cloning and PCR-based methods. Splicing of the pseudoautosomal exon 3 of XG occurs to multiple sites In Y-speciflc sequences. Transcripts detected include antisense SRY sequences and XG̃RPS4Y hybrid transcripts. The heterogeneity and low abundance of transcripts as well as the lack of maintenance of the XG open reading frame in all but one transcript argue against a specific Y-chromosome gene product. An expressed pseudogene of XG, XGPY, has been mapped to interval Yqll.21. XGPY is transcribed and subject to alternative splicing. Sequence comparison suggests that XGPY orlginated from XG by a gene duplication event in the primate lineage.

UR - http://www.scopus.com/inward/record.url?scp=0029000023&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029000023&partnerID=8YFLogxK

U2 - 10.1093/hmg/4.5.859

DO - 10.1093/hmg/4.5.859

M3 - Article

VL - 4

SP - 859

EP - 868

JO - Human Molecular Genetics

JF - Human Molecular Genetics

SN - 0964-6906

IS - 5

ER -