The impact of larval and adult dietary restriction on lifespan, reproduction and growth in the mosquito Aedes aegypti

Teresa K. Joy, Anam J. Arik, Vanessa Corby-Harris, Adiv A. Johnson, Michael A Riehle

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Dietary restriction extends lifespan in many organisms, but little is known about how it affects hematophagous arthropods. We demonstrated that diet restriction during either larval or adult stages extends Aedes aegypti lifespan. A. aegypti females fed either single or no blood meals survived 30-40% longer than those given weekly blood meals. However, mosquitoes given weekly blood meals produced far more eggs. To minimize reproduction's impact on lifespan, adult mosquitoes were fed artificial blood meals containing <10% of the protein in normal human blood, minimizing egg production. A. aegypti fed artificial blood meals containing 25. mg/ml of BSA had significantly shorter lifespans than those fed either 10 or 5. mg/ml. To assess the impact of larval dietary restriction on adult lifespan, we maintained larval A. aegypti on 2X, 1X (normal diet), 0.5X or 0.25X diets. Adult mosquitoes fed 0.5X and 0.25X larval diets survived significantly longer than those fed the 2X larval diet regardless of adult diet. In summary, dietary restriction during both larval and adult stages extends lifespan. This diet-mediated lifespan extension has important consequences for understanding how dietary restriction regulates lifespan and disease transmission.

Original languageEnglish (US)
Pages (from-to)685-690
Number of pages6
JournalExperimental Gerontology
Volume45
Issue number9
DOIs
StatePublished - Sep 2010

Fingerprint

Aedes
Nutrition
Culicidae
Reproduction
Diet
Meals
Growth
Blood
Blood Substitutes
Arthropods
Eggs
Ovum
Proteins

Keywords

  • Aging
  • Dengue
  • Dietary restriction
  • Nutrient restriction
  • Senescence

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Cell Biology
  • Endocrinology
  • Genetics
  • Molecular Biology

Cite this

The impact of larval and adult dietary restriction on lifespan, reproduction and growth in the mosquito Aedes aegypti. / Joy, Teresa K.; Arik, Anam J.; Corby-Harris, Vanessa; Johnson, Adiv A.; Riehle, Michael A.

In: Experimental Gerontology, Vol. 45, No. 9, 09.2010, p. 685-690.

Research output: Contribution to journalArticle

Joy, Teresa K. ; Arik, Anam J. ; Corby-Harris, Vanessa ; Johnson, Adiv A. ; Riehle, Michael A. / The impact of larval and adult dietary restriction on lifespan, reproduction and growth in the mosquito Aedes aegypti. In: Experimental Gerontology. 2010 ; Vol. 45, No. 9. pp. 685-690.
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