The importance of prevention of calciphylaxis in patients who are at risk and the potential fallibility of calcimimetics in the treatment of calciphylaxis for patients with secondary hyperparathyroidism

Zain Khalpey, Matthew A. Nehs, Andrew W. Elbardissi, Marcus Semel, Stefan G. Tullius

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A 43-year-old African American with end-stage renal disease (ESRD) associated with membranous nephropathy and a previously failed renal transplant had received cinacalcet to treat his secondary hyperparathyroidism. Serum calcium and phosphorus levels remained within normal limits, and serum parathyroid levels had dropped significantly following treatment initiation. However, within 7 months, the patient experienced extensive necrotic bilateral medial thigh ulcers. These were biopsied and found to be a result of calciphylaxis. The patient ultimately required an urgent subtotal parathyroidectomy and recovered well with completely healed ulcers.

Original languageEnglish (US)
Pages (from-to)68-70
Number of pages3
JournalNDT Plus
Volume3
Issue number1
DOIs
StatePublished - Feb 2010

Keywords

  • calciphylaxis
  • cinacalcet
  • hyperparathyroidism
  • sensipar

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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