The influence of intrinsic and extrinsic factors on immune system aging

Michael Badowski, Christopher L. Shultz, Yvette Eason, Nafees - Ahmad, David T. Harris

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Sex and age-matched wild-type and TCR transgenic mice were infected with cytomegalovirus (CMV) at 6 months of age and followed for 12 additional months to examine aging of the immune system. It was found that viral infection of C57Bl/6 mice resulted in accelerated aging of the immune system as shown by a loss of CD8+28+ cells and an accumulation of KLRG1+ T cells. CMV infection of OT-1 transgenic mice had no influence on immune aging of these mice which nonetheless demonstrated an accumulation of CD8+28- and KLRG1+ T cells with time. CD4+ T cells were unaffected in either strain of mice. Thus, immunological aging was found to be due to both cell-intrinsic and cell-extrinsic factors. Persistent viral infections may accelerate immunological aging but consideration must be given to individual variation in the aging process.

Original languageEnglish (US)
Pages (from-to)482-485
Number of pages4
JournalImmunobiology
Volume219
Issue number6
DOIs
StatePublished - 2014

Fingerprint

Intrinsic Factor
Immune System
Virus Diseases
T-Lymphocytes
Transgenic Mice
Cytomegalovirus Infections
Cytomegalovirus

Keywords

  • Aging
  • Immunity
  • MCMV
  • Mice
  • OT-1

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Hematology
  • Medicine(all)

Cite this

The influence of intrinsic and extrinsic factors on immune system aging. / Badowski, Michael; Shultz, Christopher L.; Eason, Yvette; Ahmad, Nafees -; Harris, David T.

In: Immunobiology, Vol. 219, No. 6, 2014, p. 482-485.

Research output: Contribution to journalArticle

Badowski, Michael ; Shultz, Christopher L. ; Eason, Yvette ; Ahmad, Nafees - ; Harris, David T. / The influence of intrinsic and extrinsic factors on immune system aging. In: Immunobiology. 2014 ; Vol. 219, No. 6. pp. 482-485.
@article{316d5759d7be40cfb56adb0a4285b059,
title = "The influence of intrinsic and extrinsic factors on immune system aging",
abstract = "Sex and age-matched wild-type and TCR transgenic mice were infected with cytomegalovirus (CMV) at 6 months of age and followed for 12 additional months to examine aging of the immune system. It was found that viral infection of C57Bl/6 mice resulted in accelerated aging of the immune system as shown by a loss of CD8+28+ cells and an accumulation of KLRG1+ T cells. CMV infection of OT-1 transgenic mice had no influence on immune aging of these mice which nonetheless demonstrated an accumulation of CD8+28- and KLRG1+ T cells with time. CD4+ T cells were unaffected in either strain of mice. Thus, immunological aging was found to be due to both cell-intrinsic and cell-extrinsic factors. Persistent viral infections may accelerate immunological aging but consideration must be given to individual variation in the aging process.",
keywords = "Aging, Immunity, MCMV, Mice, OT-1",
author = "Michael Badowski and Shultz, {Christopher L.} and Yvette Eason and Ahmad, {Nafees -} and Harris, {David T.}",
year = "2014",
doi = "10.1016/j.imbio.2014.02.008",
language = "English (US)",
volume = "219",
pages = "482--485",
journal = "Immunobiology",
issn = "0171-2985",
publisher = "Urban und Fischer Verlag GmbH und Co. KG",
number = "6",

}

TY - JOUR

T1 - The influence of intrinsic and extrinsic factors on immune system aging

AU - Badowski, Michael

AU - Shultz, Christopher L.

AU - Eason, Yvette

AU - Ahmad, Nafees -

AU - Harris, David T.

PY - 2014

Y1 - 2014

N2 - Sex and age-matched wild-type and TCR transgenic mice were infected with cytomegalovirus (CMV) at 6 months of age and followed for 12 additional months to examine aging of the immune system. It was found that viral infection of C57Bl/6 mice resulted in accelerated aging of the immune system as shown by a loss of CD8+28+ cells and an accumulation of KLRG1+ T cells. CMV infection of OT-1 transgenic mice had no influence on immune aging of these mice which nonetheless demonstrated an accumulation of CD8+28- and KLRG1+ T cells with time. CD4+ T cells were unaffected in either strain of mice. Thus, immunological aging was found to be due to both cell-intrinsic and cell-extrinsic factors. Persistent viral infections may accelerate immunological aging but consideration must be given to individual variation in the aging process.

AB - Sex and age-matched wild-type and TCR transgenic mice were infected with cytomegalovirus (CMV) at 6 months of age and followed for 12 additional months to examine aging of the immune system. It was found that viral infection of C57Bl/6 mice resulted in accelerated aging of the immune system as shown by a loss of CD8+28+ cells and an accumulation of KLRG1+ T cells. CMV infection of OT-1 transgenic mice had no influence on immune aging of these mice which nonetheless demonstrated an accumulation of CD8+28- and KLRG1+ T cells with time. CD4+ T cells were unaffected in either strain of mice. Thus, immunological aging was found to be due to both cell-intrinsic and cell-extrinsic factors. Persistent viral infections may accelerate immunological aging but consideration must be given to individual variation in the aging process.

KW - Aging

KW - Immunity

KW - MCMV

KW - Mice

KW - OT-1

UR - http://www.scopus.com/inward/record.url?scp=84899473068&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899473068&partnerID=8YFLogxK

U2 - 10.1016/j.imbio.2014.02.008

DO - 10.1016/j.imbio.2014.02.008

M3 - Article

C2 - 24661721

AN - SCOPUS:84899473068

VL - 219

SP - 482

EP - 485

JO - Immunobiology

JF - Immunobiology

SN - 0171-2985

IS - 6

ER -