The influence of objects on place field expression and size in distal hippocampal CA1

Sara N. Burke, Andrew P. Maurer, Saman Nematollahi, Ajay R. Uprety, Jenelle L. Wallace, Carol A Barnes

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The perirhinal and lateral entorhinal cortices send prominent projections to the portion of the hippocampal CA1 subfield closest to the subiculum, but relatively little is known regarding the contributions of these cortical areas to hippocampal activity patterns. The anatomical connections of the lateral entorhinal and perirhinal cortices, as well as lesion data, suggest that these brain regions may contribute to the perception of complex stimuli such as objects. The current experiments investigated the degree to which three-dimensional objects affect place field size and activity within the distal region (closest to the subiculum) of CA1. The activity of CA1 pyramidal cells was monitored as rats traversed a circular track that contained no objects in some conditions and three-dimensional objects in other conditions. In the area of CA1 that receives direct lateral entorhinal input, three factors differentiated the objects-on-track conditions from the no-object conditions: more pyramidal cells expressed place fields when objects were present, adding or removing objects from the environment led to partial remapping in CA1, and the size of place fields decreased when objects were present. In addition, a proportion of place fields remapped under conditions in which the object locations were shuffled, which suggests that at least some of the CA1 neurons' firing patterns were sensitive to a particular object in a particular location. Together, these data suggest that the activity characteristics of neurons in the areas of CA1 receiving direct input from the perirhinal and lateral entorhinal cortices are modulated by non-spatial sensory input such as three-dimensional objects.

Original languageEnglish (US)
Pages (from-to)783-801
Number of pages19
JournalHippocampus
Volume21
Issue number7
DOIs
StatePublished - Jul 2011

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Entorhinal Cortex
Pyramidal Cells
Hippocampus
Neurons
Brain

Keywords

  • Aging
  • Entorhinal cortex
  • Perirhinal cortex
  • Place fields
  • Plasticity
  • Rat

ASJC Scopus subject areas

  • Cognitive Neuroscience

Cite this

Burke, S. N., Maurer, A. P., Nematollahi, S., Uprety, A. R., Wallace, J. L., & Barnes, C. A. (2011). The influence of objects on place field expression and size in distal hippocampal CA1. Hippocampus, 21(7), 783-801. https://doi.org/10.1002/hipo.20929

The influence of objects on place field expression and size in distal hippocampal CA1. / Burke, Sara N.; Maurer, Andrew P.; Nematollahi, Saman; Uprety, Ajay R.; Wallace, Jenelle L.; Barnes, Carol A.

In: Hippocampus, Vol. 21, No. 7, 07.2011, p. 783-801.

Research output: Contribution to journalArticle

Burke, SN, Maurer, AP, Nematollahi, S, Uprety, AR, Wallace, JL & Barnes, CA 2011, 'The influence of objects on place field expression and size in distal hippocampal CA1', Hippocampus, vol. 21, no. 7, pp. 783-801. https://doi.org/10.1002/hipo.20929
Burke, Sara N. ; Maurer, Andrew P. ; Nematollahi, Saman ; Uprety, Ajay R. ; Wallace, Jenelle L. ; Barnes, Carol A. / The influence of objects on place field expression and size in distal hippocampal CA1. In: Hippocampus. 2011 ; Vol. 21, No. 7. pp. 783-801.
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