The influence of polyhexamethyleneguanidine on polyamine metabolism in mongrel rats and on the growth and metastatic spreading of transplantable Lewis lung carcinoma in C57Bl mice

S. P. Zaletok, N. M. Lyalyushko, N. K. Berdinskikh, N. A. Ignatenko, M. Lidak Yu., E. A. Baumanis, I. A. Birska

Research output: Contribution to journalArticle

Abstract

Polyhexamethyleneguanidine (PMG) has been studied for its effect on some indices of polyamine metabolism in mongrel rats after preliminary induction of ornithine decarboxylase (ODC) activity in kidneys by means of testosterone. It has been found that PMG influences the synthesis of polyamines and inhibits activity of ODC, a key enzyme of their synthesis, which causes a decrease of the polyamines content in the target organ and in biological fluids of the organism (blood and urine). The effect of PMG on the growth and metastatic spreading of the Lewis lung carcinoma was studied in C57Bl mice. It has been shown that antitumour and antimetastatic effect of PMG depends on the dose, the number of injections and the terms of the drug administration. Combined administration of ceruloplasmin and PMG reduces the toxic effect of the latter and intensifies the antitumour and antimetastatic effects, which evidences for the expediency of combined application of PMG and ceruloplasmin.

Original languageEnglish (US)
Pages (from-to)36-40
Number of pages5
JournalEksperimentalnaya Onkologiya
Volume15
Issue number6
StatePublished - Dec 1 1993
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'The influence of polyhexamethyleneguanidine on polyamine metabolism in mongrel rats and on the growth and metastatic spreading of transplantable Lewis lung carcinoma in C57Bl mice'. Together they form a unique fingerprint.

  • Cite this