Polyhexamethyleneguanidine (PMG) has been studied for its effect on some indices of polyamine metabolism in mongrel rats after preliminary induction of ornithine decarboxylase (ODC) activity in kidneys by means of testosterone. It has been found that PMG influences the synthesis of polyamines and inhibits activity of ODC, a key enzyme of their synthesis, which causes a decrease of the polyamines content in the target organ and in biological fluids of the organism (blood and urine). The effect of PMG on the growth and metastatic spreading of the Lewis lung carcinoma was studied in C57Bl mice. It has been shown that antitumour and antimetastatic effect of PMG depends on the dose, the number of injections and the terms of the drug administration. Combined administration of ceruloplasmin and PMG reduces the toxic effect of the latter and intensifies the antitumour and antimetastatic effects, which evidences for the expediency of combined application of PMG and ceruloplasmin.
|Original language||English (US)|
|Number of pages||5|
|State||Published - Dec 1 1993|
ASJC Scopus subject areas
- Cancer Research