The international registry on hand and composite tissue transplantation

Palmina Petruzzo, Marco Lanzetta, Jean Michel Dubernard, Luis Landin, Pedro Cavadas, Raimund Margreiter, Stephan Schneeberger, Warren C Breidenbach, Christina Kaufman, Jerzy Jablecki, Frédéric Schuind, Christian Dumontier

Research output: Contribution to journalArticle

229 Citations (Scopus)

Abstract

Background. The International Registry on Hand and Composite Tissue Transplantation was founded in May 2002, and the analysis of all cases with follow-up information up to July 2010 is presented here. Methods. From September 1998 to July 2010, 49 hands (17 unilateral and 16 bilateral hand transplantations, including 1 case of bilateral arm transplantation) have been reported, for a total of 33 patients. They were 31 men and 2 women (median age 32 years). Time since hand loss ranged from 2 months to 34 years, and in 46% of cases, the level of amputation was at wrist. Immunosuppressive therapy included tacrolimus, mycophenolate mofetil, sirolimus, and steroids; polyclonal or monoclonal antibodies were used for induction. Topical immunosuppression was also used in several cases. Follow-up ranges from 1 month to 11 years. Results. One patient died on day 65. Three patients transplanted in the Western countries have lost their graft, whereas until September 2009, seven hand grafts were removed for noncompliance to the immunosuppressive therapy in China. Eighty-five percent of recipients experienced at least one episode of acute rejection within the first year, and they were reversible when promptly treated. Side effects included opportunistic infections, metabolic complications, and malignancies. All patients developed protective sensibility, 90% of them developed tactile sensibility, and 82.3% also developed a discriminative sensibility. Motor recovery enabled patients to perform most daily activities. Conclusions. Hand transplantation is a complex procedure, and its success is based on patient's compliance and his or her careful evaluation before and after transplantation.

Original languageEnglish (US)
Pages (from-to)1590-1594
Number of pages5
JournalTransplantation
Volume90
Issue number12
DOIs
StatePublished - Dec 27 2010
Externally publishedYes

Fingerprint

Tissue Transplantation
Registries
Hand
Hand Transplantation
Immunosuppressive Agents
Transplantation
Mycophenolic Acid
Transplants
Opportunistic Infections
Touch
Tacrolimus
Sirolimus
Patient Compliance
Wrist
Amputation
Immunosuppression
China
Arm
Steroids
Monoclonal Antibodies

Keywords

  • Composite tissue allotransplantation
  • Hand allotransplantation

ASJC Scopus subject areas

  • Transplantation

Cite this

Petruzzo, P., Lanzetta, M., Dubernard, J. M., Landin, L., Cavadas, P., Margreiter, R., ... Dumontier, C. (2010). The international registry on hand and composite tissue transplantation. Transplantation, 90(12), 1590-1594. https://doi.org/10.1097/TP.0b013e3181ff1472

The international registry on hand and composite tissue transplantation. / Petruzzo, Palmina; Lanzetta, Marco; Dubernard, Jean Michel; Landin, Luis; Cavadas, Pedro; Margreiter, Raimund; Schneeberger, Stephan; Breidenbach, Warren C; Kaufman, Christina; Jablecki, Jerzy; Schuind, Frédéric; Dumontier, Christian.

In: Transplantation, Vol. 90, No. 12, 27.12.2010, p. 1590-1594.

Research output: Contribution to journalArticle

Petruzzo, P, Lanzetta, M, Dubernard, JM, Landin, L, Cavadas, P, Margreiter, R, Schneeberger, S, Breidenbach, WC, Kaufman, C, Jablecki, J, Schuind, F & Dumontier, C 2010, 'The international registry on hand and composite tissue transplantation', Transplantation, vol. 90, no. 12, pp. 1590-1594. https://doi.org/10.1097/TP.0b013e3181ff1472
Petruzzo P, Lanzetta M, Dubernard JM, Landin L, Cavadas P, Margreiter R et al. The international registry on hand and composite tissue transplantation. Transplantation. 2010 Dec 27;90(12):1590-1594. https://doi.org/10.1097/TP.0b013e3181ff1472
Petruzzo, Palmina ; Lanzetta, Marco ; Dubernard, Jean Michel ; Landin, Luis ; Cavadas, Pedro ; Margreiter, Raimund ; Schneeberger, Stephan ; Breidenbach, Warren C ; Kaufman, Christina ; Jablecki, Jerzy ; Schuind, Frédéric ; Dumontier, Christian. / The international registry on hand and composite tissue transplantation. In: Transplantation. 2010 ; Vol. 90, No. 12. pp. 1590-1594.
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AU - Dubernard, Jean Michel

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AU - Cavadas, Pedro

AU - Margreiter, Raimund

AU - Schneeberger, Stephan

AU - Breidenbach, Warren C

AU - Kaufman, Christina

AU - Jablecki, Jerzy

AU - Schuind, Frédéric

AU - Dumontier, Christian

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N2 - Background. The International Registry on Hand and Composite Tissue Transplantation was founded in May 2002, and the analysis of all cases with follow-up information up to July 2010 is presented here. Methods. From September 1998 to July 2010, 49 hands (17 unilateral and 16 bilateral hand transplantations, including 1 case of bilateral arm transplantation) have been reported, for a total of 33 patients. They were 31 men and 2 women (median age 32 years). Time since hand loss ranged from 2 months to 34 years, and in 46% of cases, the level of amputation was at wrist. Immunosuppressive therapy included tacrolimus, mycophenolate mofetil, sirolimus, and steroids; polyclonal or monoclonal antibodies were used for induction. Topical immunosuppression was also used in several cases. Follow-up ranges from 1 month to 11 years. Results. One patient died on day 65. Three patients transplanted in the Western countries have lost their graft, whereas until September 2009, seven hand grafts were removed for noncompliance to the immunosuppressive therapy in China. Eighty-five percent of recipients experienced at least one episode of acute rejection within the first year, and they were reversible when promptly treated. Side effects included opportunistic infections, metabolic complications, and malignancies. All patients developed protective sensibility, 90% of them developed tactile sensibility, and 82.3% also developed a discriminative sensibility. Motor recovery enabled patients to perform most daily activities. Conclusions. Hand transplantation is a complex procedure, and its success is based on patient's compliance and his or her careful evaluation before and after transplantation.

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