Abstract
Insulin resistance is invariably present in patients with the cardiometabolic syndrome and is thought to play a key role in its pathogenesis. It represents a complex interaction of maladaptive characteristics related to impaired insulin action at target organs and external factors such as genetics and environment. It is likely that the molecular factors that underlie insulin resistance and resultant hyperinsulinemia contribute to many of the clinical components of the cardiometabolic syndrome, although the precise associations remain poorly understood. Abnormalities of various adipocytokines (particularly reduced circulating levels of adiponectin and leptin) resistance may also play a role in the genesis of insulin resistance. Genetic factors are an important determinant of insulin sensitivity. Effective management of the cardiometabolic syndrome will ultimately depend on our understanding of the underlying molecular mechanisms of key components of this disorder, such as insulin resistance.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 290-294 |
| Number of pages | 5 |
| Journal | American Journal of the Medical Sciences |
| Volume | 330 |
| Issue number | 6 |
| State | Published - Dec 2005 |
| Externally published | Yes |
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Keywords
- Adipocytokines
- Cardiometabolic syndrome
- Control obesity
- Genetics
- Hyperinsulinemia
- Insulin resistance
ASJC Scopus subject areas
- Medicine(all)
Cite this
The key role of insulin resistance in the cardiometabolic syndrome. / Gill, Harvinder; Mugo, Maryann; Whaley-Connell, Adam; Stump, Craig S; Sowers, James R.
In: American Journal of the Medical Sciences, Vol. 330, No. 6, 12.2005, p. 290-294.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The key role of insulin resistance in the cardiometabolic syndrome
AU - Gill, Harvinder
AU - Mugo, Maryann
AU - Whaley-Connell, Adam
AU - Stump, Craig S
AU - Sowers, James R.
PY - 2005/12
Y1 - 2005/12
N2 - Insulin resistance is invariably present in patients with the cardiometabolic syndrome and is thought to play a key role in its pathogenesis. It represents a complex interaction of maladaptive characteristics related to impaired insulin action at target organs and external factors such as genetics and environment. It is likely that the molecular factors that underlie insulin resistance and resultant hyperinsulinemia contribute to many of the clinical components of the cardiometabolic syndrome, although the precise associations remain poorly understood. Abnormalities of various adipocytokines (particularly reduced circulating levels of adiponectin and leptin) resistance may also play a role in the genesis of insulin resistance. Genetic factors are an important determinant of insulin sensitivity. Effective management of the cardiometabolic syndrome will ultimately depend on our understanding of the underlying molecular mechanisms of key components of this disorder, such as insulin resistance.
AB - Insulin resistance is invariably present in patients with the cardiometabolic syndrome and is thought to play a key role in its pathogenesis. It represents a complex interaction of maladaptive characteristics related to impaired insulin action at target organs and external factors such as genetics and environment. It is likely that the molecular factors that underlie insulin resistance and resultant hyperinsulinemia contribute to many of the clinical components of the cardiometabolic syndrome, although the precise associations remain poorly understood. Abnormalities of various adipocytokines (particularly reduced circulating levels of adiponectin and leptin) resistance may also play a role in the genesis of insulin resistance. Genetic factors are an important determinant of insulin sensitivity. Effective management of the cardiometabolic syndrome will ultimately depend on our understanding of the underlying molecular mechanisms of key components of this disorder, such as insulin resistance.
KW - Adipocytokines
KW - Cardiometabolic syndrome
KW - Control obesity
KW - Genetics
KW - Hyperinsulinemia
KW - Insulin resistance
UR - http://www.scopus.com/inward/record.url?scp=29244436880&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=29244436880&partnerID=8YFLogxK
M3 - Article
C2 - 16355013
AN - SCOPUS:29244436880
VL - 330
SP - 290
EP - 294
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
SN - 0002-9629
IS - 6
ER -