The locus C11orf30 increases susceptibility to poly-sensitization

A. F.S. Amaral, C. Minelli, S. Guerra, M. Wjst, N. Probst-Hensch, I. Pin, C. Svanes, C. Janson, J. Heinrich, D. L. Jarvis

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

A number of genetic variants have been associated with allergic sensitization, but whether these are allergen specific or increase susceptibility to poly-sensitization is unknown. Using data from the large multicentre population-based European Community Respiratory Health Survey, we assessed the association between 10 loci and specific IgE and skin prick tests to individual allergens and poly-sensitization. We found that the 10 loci associate with sensitization to different allergens in a nonspecific manner and that one in particular, C11orf30-rs2155219, doubles the risk of poly-sensitization (specific IgE/4 allergens: OR = 1.81, 95% CI 0.80-4.24; skin prick test/4+ allergens: OR = 2.27, 95% CI 1.34-3.95). The association of rs2155219 with higher levels of expression of C11orf30, which may be involved in transcription repression of interferon-stimulated genes, and its association with sensitization to multiple allergens suggest that this locus is highly relevant for atopy.

Original languageEnglish (US)
Pages (from-to)328-333
Number of pages6
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume70
Issue number3
DOIs
StatePublished - Mar 1 2015

Keywords

  • allergens
  • allergic sensitization
  • genes for atopy
  • poly-sensitization

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Amaral, A. F. S., Minelli, C., Guerra, S., Wjst, M., Probst-Hensch, N., Pin, I., Svanes, C., Janson, C., Heinrich, J., & Jarvis, D. L. (2015). The locus C11orf30 increases susceptibility to poly-sensitization. Allergy: European Journal of Allergy and Clinical Immunology, 70(3), 328-333. https://doi.org/10.1111/all.12557