The mammalian urine concentrating mechanism: Hypotheses and uncertainties

Anita T. Layton, Harold E. Layton, William H. Dantzler, Thomas L. Pannabecker

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

The urine concentrating mechanism of the mammalian kidney, which can produce a urine that is substantially more concentrated than blood plasma during periods of water deprivation, is one of the enduring mysteries in traditional physiology. Owing to the complex lateral and axial relationships of tubules and vessels, in both the outer and inner medulla, the urine concentrating mechanism may only be fully understood in terms of the kidney's three-dimensional functional architecture and its implications for preferential interactions among tubules and vessels

Original languageEnglish (US)
Pages (from-to)250-256
Number of pages7
JournalPhysiology
Volume24
Issue number4
DOIs
StatePublished - Aug 1 2009

ASJC Scopus subject areas

  • Physiology

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