The measurement of adenoma occurrence

M. Aickin, D. S. Alberts

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Adenomatous polyps are regarded as the dominant precursor lesion of colon cancer. For four decades the occurrence of adenomas has been investigated, both in observational studies and in controlled, randomized cancer-prevention studies. During this period, little consensus has been reached with regard to the data that should be reported in such studies. The emerging consensus on the methods of analysing the results does not have a firm biostatistical basis, and does not deal appropriately with the phenomenon of colonoscopy avoidance. We review a simple biostatistical method that is appropriate, and apply it to a selected recent series of studies. Our finding is that there are common patterns of adenoma occurrence across these studies, with a rate of 0.3-0.4 per year in the first year following polypectomy, dropping to 0.1-0.15 in subsequent years. The method of analysis also serves to highlight exceptions to this pattern.

Original languageEnglish (US)
Pages (from-to)43-48
Number of pages6
JournalEuropean Journal of Cancer Prevention
Volume5
Issue number1
StatePublished - 1996

Keywords

  • Colon cancer
  • Incidence rate
  • Polyp recurrence

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

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