The mechanism of non-homologous end-joining: A synopsis of synapsis

Eric Weterings, Dik C. Van Gent

Research output: Contribution to journalReview articlepeer-review

159 Scopus citations

Abstract

Repair of DNA double-strand breaks (DSBs) by non-homologous end-joining (NHEJ) is required for resistance to genotoxic agents, such as ionizing radiation, but also for proper development of the vertebrate immune system. Much progress has been made in identifying the factors that are involved in this repair pathway. We are now entering the phase in which we begin to understand basic concepts of the reaction mechanism and regulation of non-homologous end-joining. This review concentrates on novel insights into damage recognition and subsequent tethering, processing and joining of DNA ends.

Original languageEnglish (US)
Pages (from-to)1425-1435
Number of pages11
JournalDNA Repair
Volume3
Issue number11
DOIs
StatePublished - Nov 2 2004
Externally publishedYes

Keywords

  • DNA double-strand-breaks
  • Non-homologous end-joining

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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