The mechanism of non-homologous end-joining: A synopsis of synapsis

Eric - Weterings, Dik C. Van Gent

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

Repair of DNA double-strand breaks (DSBs) by non-homologous end-joining (NHEJ) is required for resistance to genotoxic agents, such as ionizing radiation, but also for proper development of the vertebrate immune system. Much progress has been made in identifying the factors that are involved in this repair pathway. We are now entering the phase in which we begin to understand basic concepts of the reaction mechanism and regulation of non-homologous end-joining. This review concentrates on novel insights into damage recognition and subsequent tethering, processing and joining of DNA ends.

Original languageEnglish (US)
Pages (from-to)1425-1435
Number of pages11
JournalDNA Repair
Volume3
Issue number11
DOIs
StatePublished - Nov 2 2004
Externally publishedYes

Fingerprint

Chromosome Pairing
Double-Stranded DNA Breaks
Ionizing Radiation
Joining
Vertebrates
Immune System
DNA
Repair
Immune system
Ionizing radiation
Processing

Keywords

  • DNA double-strand-breaks
  • Non-homologous end-joining

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

The mechanism of non-homologous end-joining : A synopsis of synapsis. / Weterings, Eric -; Van Gent, Dik C.

In: DNA Repair, Vol. 3, No. 11, 02.11.2004, p. 1425-1435.

Research output: Contribution to journalArticle

Weterings, Eric - ; Van Gent, Dik C. / The mechanism of non-homologous end-joining : A synopsis of synapsis. In: DNA Repair. 2004 ; Vol. 3, No. 11. pp. 1425-1435.
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