The michael addition of sulfur anions to β,β-substituted Nα-formyl-α,β-dehydroamino acid esters

C. Freeman Stanfield, Victor J Hruby

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The addition of lithium benzylthiolates to Nα-formyl-α,β-dehydro-α-amino acid esters gave protected Nα-formyl-β-S-benzyl-β,S-dialkyl- cysteine esters. Hydrolysis and Nα-protection produced β,β-dialkyl-cysteines which can be used for peptide synthesis.

Original languageEnglish (US)
Pages (from-to)531-543
Number of pages13
JournalSynthetic Communications
Volume18
Issue number5
DOIs
StatePublished - Apr 1 1988

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Sulfur
Anions
Cysteine
Esters
Acids
Lithium
Hydrolysis
Amino Acids
Peptides

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

The michael addition of sulfur anions to β,β-substituted Nα-formyl-α,β-dehydroamino acid esters. / Freeman Stanfield, C.; Hruby, Victor J.

In: Synthetic Communications, Vol. 18, No. 5, 01.04.1988, p. 531-543.

Research output: Contribution to journalArticle

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