The Mid-infrared Imager, Spectrometer, Coronagraph (MISC) is one of the instruments studied both for the Origins Space Telescope (OST) Mission Concept 1 and 2. The MISC for OST Mission Concept 1 consists of the MISC imager and spectrometer module (MISC I and S), the MISC coronagraph module (MISC COR) and the MISC transit spectrometer module (MISC TRA). The MISC I and S offers (1) a wide field (3 arcminx3 arcmin) imaging and low-resolution spectroscopic capability with filters and grisms for 6-38 μm, (2) a medium-resolution (R∼1,000) Integral Field Unit (IFU) spectroscopic capability for 5- 38 μm and (3) a high-resolution (R∼25,000) slit spectroscopic capability for 12-18 μm and 25-36 μm. The MISC COR module employs PIAACMC coronagraphy method and covers 6-38 μm achieving 10-7 contrast at 0.5 arcsec from the central star. The MISC TRA module employs a densified pupil spectroscopic design to achieve 3-5 ppm of spectro-photometric stability and covers 5-26 μm with R=100-300. The MISC for OST Mission Concept 2 consists of the MISC wide field imager module (MISC WFI) and the MISC transit Spectrometer module (MISC TRA). The MISC WFI offers a wide field (3 arcmin ×3 arcmin) imaging and low-resolution spectroscopic capabilities with filters and grisms for 6-28μm. The MISC TRA module in the OST Mission Concept 2 also employs the densified pupil spectroscopic design to achieve <5 ppm of spectro-photometric stability and covers 4-22 μm with R=100-300. The highest ever spectrophotometric stability achieved by MISC TRA enables to detect bio-signatures (e.g., ozone, water, and methane) in habitable worlds in both primary and secondary transits of exoplanets and makes the OST a powerful tool to bring an revolutionary progress in exoplanet sciences. Combined with the spectroscopic capability in the FIR provided by other OST instruments, the MISC widens the wavelength coverage of OST down to 5μm, which makes the OST a powerful tool to diagnose the physical and chemical condition of the ISM using dust features, molecules lines and atomic and ionic lines. The MISC also provides the OST with a focal plane guiding function for the other OST science instruments as well as its own use.