TY - JOUR
T1 - The morphology of proximal tibiofibular joint (PTFJ) predicts incident radiographic osteoarthritis
T2 - data from Osteoarthritis Initiative
AU - Chang, J.
AU - Zhu, Z.
AU - Han, W.
AU - Zhao, Y.
AU - Kwoh, C. K.
AU - Lynch, J. A.
AU - Hunter, D. J.
AU - Ding, C.
N1 - Funding Information:
This study and image acquisition were fund by the OAI study and POMA study. The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and the National Institute on Aging (NIA) lead this initiative at the National Institutes of Health (NIH). Private funding partners included GlaxoSmithKline , Merck & Co.,Inc. , Novartis Pharmaceuticals Corporation , and Pfizer . Private sector funding for the OAI is being managed by the Foundation for the National Institutes of Health. The POMA study was funded by the NIH's National Heart, Lung, and Blood Institute .
PY - 2020/2
Y1 - 2020/2
N2 - Objective: To determine whether the morphology of proximal tibiofibular joint (PTFJ) is associated with increased risk of incident radiographic osteoarthritis (iROA) over 4 years in the OA Initiative (OAI) study. Methods: A nested matched case–control study design was used to select participants from OAI study. Case knees were defined as those with iROA. Control knees were matched one-to-one by sex, age and radiographic status with case knees. T2-weighted MR images were assessed at P0 (the visit when incident ROA was found on radiograph), P1 (1 year prior to P0) and at OAI baseline. The contacting area of PTFJ (S) and its projection areas onto the horizontal (load-bearing area, Sτ), sagittal (lateral stress-bolstering area, Sφ) and coronal plane (posterior stress-bolstering area, Sυ) were assessed, respectively. Results: 354 case knees and 354 matched control knees were included, with a mean age of 60 and a mean body mass index (BMI) of 28 kg/m2. Baseline PTFJ morphological parameters (S, Sτ and Sυ) were significantly associated with iROA over 4 years, and these associations remained unchanged after adjustment for BMI, number of knee bending activities, self-reported knee injury and surgery. S, Sτ and Sυ were also significantly associated with iROA at P1 and P0. In subgroup analysed, S, Sτ and Sυ were associated with risks of incident joint space narrowing in the medial, but not the lateral tibiofemoral compartment. Conclusion: Greater contacting area, load-bearing area and posterior stress-bolstering area of PTFJ were associated with increased risks of iROA, largely in the medial tibiofemoral compartment.
AB - Objective: To determine whether the morphology of proximal tibiofibular joint (PTFJ) is associated with increased risk of incident radiographic osteoarthritis (iROA) over 4 years in the OA Initiative (OAI) study. Methods: A nested matched case–control study design was used to select participants from OAI study. Case knees were defined as those with iROA. Control knees were matched one-to-one by sex, age and radiographic status with case knees. T2-weighted MR images were assessed at P0 (the visit when incident ROA was found on radiograph), P1 (1 year prior to P0) and at OAI baseline. The contacting area of PTFJ (S) and its projection areas onto the horizontal (load-bearing area, Sτ), sagittal (lateral stress-bolstering area, Sφ) and coronal plane (posterior stress-bolstering area, Sυ) were assessed, respectively. Results: 354 case knees and 354 matched control knees were included, with a mean age of 60 and a mean body mass index (BMI) of 28 kg/m2. Baseline PTFJ morphological parameters (S, Sτ and Sυ) were significantly associated with iROA over 4 years, and these associations remained unchanged after adjustment for BMI, number of knee bending activities, self-reported knee injury and surgery. S, Sτ and Sυ were also significantly associated with iROA at P1 and P0. In subgroup analysed, S, Sτ and Sυ were associated with risks of incident joint space narrowing in the medial, but not the lateral tibiofemoral compartment. Conclusion: Greater contacting area, load-bearing area and posterior stress-bolstering area of PTFJ were associated with increased risks of iROA, largely in the medial tibiofemoral compartment.
KW - Magnetic resonance image (MRI)
KW - Osteoarthritis (OA)
KW - Proximal tibiofibular joint (PTFJ)
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U2 - 10.1016/j.joca.2019.11.001
DO - 10.1016/j.joca.2019.11.001
M3 - Article
C2 - 31733306
AN - SCOPUS:85076205089
VL - 28
SP - 208
EP - 214
JO - Osteoarthritis and Cartilage
JF - Osteoarthritis and Cartilage
SN - 1063-4584
IS - 2
ER -