The Nebulin family: An actin support group

Christopher T. Pappas, Katherine T. Bliss, Anke Zieseniss, Carol Gregorio

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Nebulin, a giant, actin-binding protein, is the largest member of a family of proteins (including N-RAP, nebulette, lasp-1 and lasp-2) that are assembled in a variety of cytoskeletal structures, and expressed in different tissues. For decades, nebulin has been thought to act as a molecular ruler, specifying the precise length of actin filaments in skeletal muscle. However, emerging evidence suggests that nebulin should not be viewed as a ruler but as an actin filament stabilizer required for length maintenance. Nebulin has also been implicated recently in an array of regulatory functions independent of its role in actin filament length regulation. In this review, we discuss the current evolutionary, biochemical, and functional data for the nebulin family of proteins - a family whose members, both large and small, function as cytoskeletal scaffolds and stabilizers.

Original languageEnglish (US)
Pages (from-to)29-37
Number of pages9
JournalTrends in Cell Biology
Volume21
Issue number1
DOIs
StatePublished - Jan 2011

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Self-Help Groups
Actins
Actin Cytoskeleton
Microfilament Proteins
Skeletal Muscle
Proteins
Maintenance
nebulin

ASJC Scopus subject areas

  • Cell Biology

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The Nebulin family : An actin support group. / Pappas, Christopher T.; Bliss, Katherine T.; Zieseniss, Anke; Gregorio, Carol.

In: Trends in Cell Biology, Vol. 21, No. 1, 01.2011, p. 29-37.

Research output: Contribution to journalArticle

Pappas, Christopher T. ; Bliss, Katherine T. ; Zieseniss, Anke ; Gregorio, Carol. / The Nebulin family : An actin support group. In: Trends in Cell Biology. 2011 ; Vol. 21, No. 1. pp. 29-37.
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