The neural crest is contiguous with the cardiac conduction system in the mouse embryo: A role in induction?

Robert E. Poelmann, Monique R.M. Jongbloed, Daniel G.M. Molin, Madelon L. Fekkes, Zhiyong Wang, Glenn I. Fishman, Tom Doetschman, Mohamad Azhar, Adriana C. Gittenberger-De Groot

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


In this study we present data on the spatial relationship between neural crest-derived cells (NCC) and the specialized cardiac conduction system (CCS) in the developing murine heart. Using Wnt1-Cre/R26R conditional reporter mice that express β-galactosidase from ROSA26 upon Cre-mediated recombination, two populations of NCC are seen: one migrates through the arterial pole and contributes to the bundle branches, whereas the second population enters by way of the venous pole and provides cells to the sinoatrial and atrioventricular node areas. The CCS/lacZ construct is found in the myocardium of the early embryonic heart and afterward only persists in the definitive CCS and is acknowledged as a reporter for the developing conduction system. The contiguous expression of both reporters is suggestive for a potential role of cardiac NCC in the induction of the final differentiation of the CCS.

Original languageEnglish (US)
Pages (from-to)389-393
Number of pages5
JournalAnatomy and Embryology
Issue number5
StatePublished - Aug 2004
Externally publishedYes


  • Bundle branches
  • Heart development
  • His bundle
  • Micro-array
  • Reporter gene
  • Transforming growth factor beta

ASJC Scopus subject areas

  • Anatomy
  • Embryology
  • Developmental Biology
  • Cell Biology


Dive into the research topics of 'The neural crest is contiguous with the cardiac conduction system in the mouse embryo: A role in induction?'. Together they form a unique fingerprint.

Cite this