The neurobiology of memory changes in normal aging

C. A. Erickson, Carol A Barnes

Research output: Contribution to journalArticle

184 Citations (Scopus)

Abstract

Cognitive alterations occur over the lifespan of every species studied and have been quantified carefully in humans, other primates and rodents. Correspondingly, changes in hippocampal function have been associated with a number of observed memory impairments across species. It appears that humans, alone, show Alzheimer's disease-like cognitive and neural pathology spontaneously. Thus, a comparison of normal age-related changes in cognition in other animals can help disambiguate the boundary between normal and pathological states of aging in humans. Another important contribution made from studying aging in non-human species is the ability to examine, in more detail, the basic neural mechanisms that may be responsible for brain aging in these species. So far, most of the functional neurobiological studies have been conducted in the aged rat. We propose that the link between rodent and human work can be made much stronger by combining neurophysiological and behavioral investigation of normal aging in the non-human primate.

Original languageEnglish (US)
Pages (from-to)61-69
Number of pages9
JournalExperimental Gerontology
Volume38
Issue number1-2
DOIs
StatePublished - Jan 2003

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Neurobiology
Aging of materials
Data storage equipment
Primates
Rodentia
Aptitude
Pathology
Cognition
Rats
Brain
Alzheimer Disease
Animals

Keywords

  • Ensemble dynamics
  • Hippocampal plasticity
  • Humans
  • Learning and memory
  • Monkeys
  • Normal aging
  • Rats

ASJC Scopus subject areas

  • Aging
  • Medicine(all)

Cite this

The neurobiology of memory changes in normal aging. / Erickson, C. A.; Barnes, Carol A.

In: Experimental Gerontology, Vol. 38, No. 1-2, 01.2003, p. 61-69.

Research output: Contribution to journalArticle

Erickson, C. A. ; Barnes, Carol A. / The neurobiology of memory changes in normal aging. In: Experimental Gerontology. 2003 ; Vol. 38, No. 1-2. pp. 61-69.
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