The neurobiology of skeletal pain

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Disorders of the skeleton are one of the most common causes of chronic pain and long-term physical disability in the world. Chronic skeletal pain is caused by a remarkably diverse group of conditions including trauma-induced fracture, osteoarthritis, osteoporosis, low back pain, orthopedic procedures, celiac disease, sickle cell disease and bone cancer. While these disorders are diverse, what they share in common is that when chronic skeletal pain occurs in these disorders, there are currently few therapies that can fully control the pain without significant unwanted side effects. In this review we focus on recent advances in our knowledge concerning the unique population of primary afferent sensory nerve fibers that innervate the skeleton, the nociceptive and neuropathic mechanisms that are involved in driving skeletal pain, and the neurochemical and structural changes that can occur in sensory and sympathetic nerve fibers and the CNS in chronic skeletal pain. We also discuss therapies targeting nerve growth factor or sclerostin for treating skeletal pain. These therapies have provided unique insight into the factors that drive skeletal pain and the structural decline that occurs in the aging skeleton. We conclude by discussing how these advances have changed our understanding and potentially the therapeutic options for treating and/or preventing chronic pain in the injured, diseased and aged skeleton. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.

Original languageEnglish (US)
Pages (from-to)508-519
Number of pages12
JournalEuropean Journal of Neuroscience
Volume39
Issue number3
DOIs
StatePublished - Feb 2014

Fingerprint

Neurobiology
Chronic Pain
Skeleton
Pain
Nerve Fibers
Orthopedic Procedures
Adrenergic Fibers
Bone Neoplasms
Public Sector
Sickle Cell Anemia
Celiac Disease
Nerve Growth Factor
Therapeutics
Low Back Pain
Osteoarthritis
Osteoporosis
Wounds and Injuries
Population

Keywords

  • Age
  • Bone
  • Cartilage
  • CRPS
  • Marrow
  • Nociceptor

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The neurobiology of skeletal pain. / Mantyh, Patrick W.

In: European Journal of Neuroscience, Vol. 39, No. 3, 02.2014, p. 508-519.

Research output: Contribution to journalArticle

@article{f67728eb008345e0b3cca0566ca95a6a,
title = "The neurobiology of skeletal pain",
abstract = "Disorders of the skeleton are one of the most common causes of chronic pain and long-term physical disability in the world. Chronic skeletal pain is caused by a remarkably diverse group of conditions including trauma-induced fracture, osteoarthritis, osteoporosis, low back pain, orthopedic procedures, celiac disease, sickle cell disease and bone cancer. While these disorders are diverse, what they share in common is that when chronic skeletal pain occurs in these disorders, there are currently few therapies that can fully control the pain without significant unwanted side effects. In this review we focus on recent advances in our knowledge concerning the unique population of primary afferent sensory nerve fibers that innervate the skeleton, the nociceptive and neuropathic mechanisms that are involved in driving skeletal pain, and the neurochemical and structural changes that can occur in sensory and sympathetic nerve fibers and the CNS in chronic skeletal pain. We also discuss therapies targeting nerve growth factor or sclerostin for treating skeletal pain. These therapies have provided unique insight into the factors that drive skeletal pain and the structural decline that occurs in the aging skeleton. We conclude by discussing how these advances have changed our understanding and potentially the therapeutic options for treating and/or preventing chronic pain in the injured, diseased and aged skeleton. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.",
keywords = "Age, Bone, Cartilage, CRPS, Marrow, Nociceptor",
author = "Mantyh, {Patrick W}",
year = "2014",
month = "2",
doi = "10.1111/ejn.12462",
language = "English (US)",
volume = "39",
pages = "508--519",
journal = "European Journal of Neuroscience",
issn = "0953-816X",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - The neurobiology of skeletal pain

AU - Mantyh, Patrick W

PY - 2014/2

Y1 - 2014/2

N2 - Disorders of the skeleton are one of the most common causes of chronic pain and long-term physical disability in the world. Chronic skeletal pain is caused by a remarkably diverse group of conditions including trauma-induced fracture, osteoarthritis, osteoporosis, low back pain, orthopedic procedures, celiac disease, sickle cell disease and bone cancer. While these disorders are diverse, what they share in common is that when chronic skeletal pain occurs in these disorders, there are currently few therapies that can fully control the pain without significant unwanted side effects. In this review we focus on recent advances in our knowledge concerning the unique population of primary afferent sensory nerve fibers that innervate the skeleton, the nociceptive and neuropathic mechanisms that are involved in driving skeletal pain, and the neurochemical and structural changes that can occur in sensory and sympathetic nerve fibers and the CNS in chronic skeletal pain. We also discuss therapies targeting nerve growth factor or sclerostin for treating skeletal pain. These therapies have provided unique insight into the factors that drive skeletal pain and the structural decline that occurs in the aging skeleton. We conclude by discussing how these advances have changed our understanding and potentially the therapeutic options for treating and/or preventing chronic pain in the injured, diseased and aged skeleton. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.

AB - Disorders of the skeleton are one of the most common causes of chronic pain and long-term physical disability in the world. Chronic skeletal pain is caused by a remarkably diverse group of conditions including trauma-induced fracture, osteoarthritis, osteoporosis, low back pain, orthopedic procedures, celiac disease, sickle cell disease and bone cancer. While these disorders are diverse, what they share in common is that when chronic skeletal pain occurs in these disorders, there are currently few therapies that can fully control the pain without significant unwanted side effects. In this review we focus on recent advances in our knowledge concerning the unique population of primary afferent sensory nerve fibers that innervate the skeleton, the nociceptive and neuropathic mechanisms that are involved in driving skeletal pain, and the neurochemical and structural changes that can occur in sensory and sympathetic nerve fibers and the CNS in chronic skeletal pain. We also discuss therapies targeting nerve growth factor or sclerostin for treating skeletal pain. These therapies have provided unique insight into the factors that drive skeletal pain and the structural decline that occurs in the aging skeleton. We conclude by discussing how these advances have changed our understanding and potentially the therapeutic options for treating and/or preventing chronic pain in the injured, diseased and aged skeleton. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.

KW - Age

KW - Bone

KW - Cartilage

KW - CRPS

KW - Marrow

KW - Nociceptor

UR - http://www.scopus.com/inward/record.url?scp=84893394214&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893394214&partnerID=8YFLogxK

U2 - 10.1111/ejn.12462

DO - 10.1111/ejn.12462

M3 - Article

C2 - 24494689

AN - SCOPUS:84893394214

VL - 39

SP - 508

EP - 519

JO - European Journal of Neuroscience

JF - European Journal of Neuroscience

SN - 0953-816X

IS - 3

ER -