The neuronal basis of direction selectivity in lobula plate tangential cells

Timothy Melano, Charles M. Higgins

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Using a neuronally based computational model of the fly's visual elementary motion detection (EMD) system, the effects of picrotoxin, a GABA receptor antagonist, were modeled to investigate the role of various GABAergic cells in direction selectivity. By comparing the results of our simulation of an anatomically correct model to previously published electrophysiological results, this study supports the hypothesis that EMD outputs integrated into tangential cells are weakly directional, although the tangential cells themselves respond to moving stimuli in a strongly directional manner.

Original languageEnglish (US)
Pages (from-to)153-159
Number of pages7
Issue numberSPEC. ISS.
StatePublished - Jun 2005


  • Diptera
  • Elementary motion detection
  • Tangential cells
  • Visual motion

ASJC Scopus subject areas

  • Computer Science Applications
  • Cognitive Neuroscience
  • Artificial Intelligence


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