Abstract
This study tested prefrontal and hippocampal functions in a sample of 28 school-aged (M = 14.7 years, SD = 2.7) individuals with Down syndrome (DS) compared with 28 (M = 4.9 years, SD = .75) typically developing children individually matched on mental age (MA). Both neuropsychological domains were tested with multiple behavioral measures. Benchmark measures of verbal and spatial function demonstrated that this DS sample was similar to others in the literature. The main finding was a significant Group × Domain interaction effect indicating differential hippocampal dysfunction in the group with DS. However, there was a moderate partial correlation (r = .54, controlling for chronological age) between hippocampal and prefrontal composite scores in the DS group, and both composites contributed unique variance to the prediction of MA and adaptive behavior in that group. In sum, these results indicate a particular weakness in hippocampal functions in DS in the context of overall cognitive dysfunction. It is interesting that these results are similar to what has been found in a mouse model of DS. Such a model will make it easier to understand the neurobiological mechanisms that lead to the development of hippocampal dysfunction in DS.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 75-93 |
| Number of pages | 19 |
| Journal | Child Development |
| Volume | 74 |
| Issue number | 1 |
| State | Published - Jan 2003 |
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ASJC Scopus subject areas
- Psychology(all)
- Developmental and Educational Psychology
Cite this
The Neuropsychology of Down Syndrome : Evidence for Hippocampal Dysfunction. / Pennington, Bruce F.; Moon, Jennifer; Edgin, Jamie O; Stedron, Jennifer; Nadel, Lynn.
In: Child Development, Vol. 74, No. 1, 01.2003, p. 75-93.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Neuropsychology of Down Syndrome
T2 - Evidence for Hippocampal Dysfunction
AU - Pennington, Bruce F.
AU - Moon, Jennifer
AU - Edgin, Jamie O
AU - Stedron, Jennifer
AU - Nadel, Lynn
PY - 2003/1
Y1 - 2003/1
N2 - This study tested prefrontal and hippocampal functions in a sample of 28 school-aged (M = 14.7 years, SD = 2.7) individuals with Down syndrome (DS) compared with 28 (M = 4.9 years, SD = .75) typically developing children individually matched on mental age (MA). Both neuropsychological domains were tested with multiple behavioral measures. Benchmark measures of verbal and spatial function demonstrated that this DS sample was similar to others in the literature. The main finding was a significant Group × Domain interaction effect indicating differential hippocampal dysfunction in the group with DS. However, there was a moderate partial correlation (r = .54, controlling for chronological age) between hippocampal and prefrontal composite scores in the DS group, and both composites contributed unique variance to the prediction of MA and adaptive behavior in that group. In sum, these results indicate a particular weakness in hippocampal functions in DS in the context of overall cognitive dysfunction. It is interesting that these results are similar to what has been found in a mouse model of DS. Such a model will make it easier to understand the neurobiological mechanisms that lead to the development of hippocampal dysfunction in DS.
AB - This study tested prefrontal and hippocampal functions in a sample of 28 school-aged (M = 14.7 years, SD = 2.7) individuals with Down syndrome (DS) compared with 28 (M = 4.9 years, SD = .75) typically developing children individually matched on mental age (MA). Both neuropsychological domains were tested with multiple behavioral measures. Benchmark measures of verbal and spatial function demonstrated that this DS sample was similar to others in the literature. The main finding was a significant Group × Domain interaction effect indicating differential hippocampal dysfunction in the group with DS. However, there was a moderate partial correlation (r = .54, controlling for chronological age) between hippocampal and prefrontal composite scores in the DS group, and both composites contributed unique variance to the prediction of MA and adaptive behavior in that group. In sum, these results indicate a particular weakness in hippocampal functions in DS in the context of overall cognitive dysfunction. It is interesting that these results are similar to what has been found in a mouse model of DS. Such a model will make it easier to understand the neurobiological mechanisms that lead to the development of hippocampal dysfunction in DS.
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M3 - Article
C2 - 12625437
AN - SCOPUS:0038687498
VL - 74
SP - 75
EP - 93
JO - Child Development
JF - Child Development
SN - 0009-3920
IS - 1
ER -