The oft-neglected role of parietal EEG asymmetry and risk for major depressive disorder

Jennifer L. Stewart, David N. Towers, James A. Coan, John JB Allen

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Relatively less right parietal activity may reflect reduced arousal and signify risk for major depressive disorder (MDD). Inconsistent findings with parietal electroencephalographic (EEG) asymmetry, however, suggest issues such as anxiety comorbidity and sex differences have yet to be resolved. Resting parietal EEG asymmetry was assessed in 306 individuals (31% male) with (n=143) and without (n=163) a DSM-IV diagnosis of lifetime MDD and no comorbid anxiety disorders. Past MDD+ women displayed relatively less right parietal activity than current MDD+ and MDD- women, replicating prior work. Recent caffeine intake, an index of arousal, moderated the relationship between depression and EEG asymmetry for women and men. Findings suggest that sex differences and arousal should be examined in studies of depression and regional brain activity.

Original languageEnglish (US)
Pages (from-to)82-95
Number of pages14
JournalPsychophysiology
Volume48
Issue number1
DOIs
StatePublished - Jan 2011

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Major Depressive Disorder
Arousal
Sex Characteristics
Depression
Caffeine
Anxiety Disorders
Diagnostic and Statistical Manual of Mental Disorders
Comorbidity
Anxiety
Brain

Keywords

  • Depression
  • EEG asymmetry
  • Endophenotype

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Experimental and Cognitive Psychology
  • Neuropsychology and Physiological Psychology

Cite this

The oft-neglected role of parietal EEG asymmetry and risk for major depressive disorder. / Stewart, Jennifer L.; Towers, David N.; Coan, James A.; Allen, John JB.

In: Psychophysiology, Vol. 48, No. 1, 01.2011, p. 82-95.

Research output: Contribution to journalArticle

Stewart, Jennifer L. ; Towers, David N. ; Coan, James A. ; Allen, John JB. / The oft-neglected role of parietal EEG asymmetry and risk for major depressive disorder. In: Psychophysiology. 2011 ; Vol. 48, No. 1. pp. 82-95.
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