The ontogeny of specific binding sites for the calcium channel antagonist, nitrendipine, in mouse heart and brain

Russ D. Erman, Henry I. Yamamura, William R. Roeske

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The high specific activity radioligand, [3H]nitrendipine, was used to study the ontogeny of high affinity binding sites in mouse heart and brain. A period of rapid postnatal brain growth is reflected by a dramatic increase in the receptor density (Bmax) between 7 and 21 days of age, reaching an adult Bmax value of 10.7 ± 0.38 fmol/mg tissue. A more linear rise in cardiac binding site density to 16.8 ± 2.0 fmol/mg tissue was found while no change in Kd of either tissue was noted during development.

Original languageEnglish (US)
Pages (from-to)327-331
Number of pages5
JournalBrain Research
Volume278
Issue number1-2
DOIs
StatePublished - Nov 14 1983
Externally publishedYes

Keywords

  • brain
  • calcium channels
  • heart
  • mice
  • nitrendipine
  • ontogeny

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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