The outcome after aortic valve-sparing (David) operation in 179 patients: A single-centre experience

Sergey Leontyev, Constanze Trommer, Sreekumar Subramanian, Sven Lehmann, Yaroslava Dmitrieva, Martin Misfeld, Friedrich W. Mohr, Michael A. Borger

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Objectives: The David aortic valve-sparing reimplantation (AVr-D) operation is increasingly being used in patients with aortic root aneurysmal disease and pliable aortic cusps. The objective of this study was to assess our early and medium-term outcomes with the AVr-D operation. Methods: Between 2003 and 2011, a total of 179 patients underwent AVr-D procedures. The mean patient age was 49.7 ± 15.1 years, and 23.5% (n = 42) were females. Marfan syndrome was present in 17.3% of patients (n = 31), and acute Type A aortic dissection in 15.6% (n = 28). Clinical follow-up was 100% complete and was 1.8 ± 1.6 years (0 days to 7.5 years) long. Echocardiographic follow-up was performed 2.2 ± 1.5 years (0 days to 7.5 years) postoperatively and was 77% complete. Results: Early mortality was 1.1% (n = 2), with both deaths occurring in patients with Type A dissection. Pre-discharge echocardiography revealed no patients with >2+ aortic insufficiency (AI), 19.6% of patients (n = 34) with 1+ or 2+ AI and 80.4% of patients (n = 145) with trace or no AI. Left ventricular end-diastolic diameters decreased significantly from 5.6 ± 0.9 to 5.1 ± 0.8 cm early postoperatively (P < 0.01). Transvalvular maximum gradients were similar before discharge and at last follow-up (10.6 ± 5.4 vs. 10.0 ± 8.2 mmHg, P = 0.4). AI grade increased significantly over time (0.3 ± 0.4 before discharge vs. 0.5 ± 0.6 at follow-up, P = 0.01), but remained less than moderate in 93.6% of patients. Four patients required aortic valve re-replacement during follow-up, two due to early endocarditis and two due to non-coronary leaflet prolapse in Marfan patients. Five-year freedom from aortic valve reoperation was 95.9 ± 2.0%. Conclusions: AVr-D is associated with a low mortality and morbidity rate, even in patients with Type A aortic dissection. Although a slightly higher rate of recurrent AI may be present in patients with Marfan syndrome, freedom from recurrent AI and reoperation remains excellent during medium-term follow-up. The David operation should be considered the gold standard for patients with proximal aortic root pathology (aneurysm or dissection) and pliable aortic cusps.

Original languageEnglish (US)
Article numberezs011
Pages (from-to)261-267
Number of pages7
JournalEuropean Journal of Cardio-thoracic Surgery
Volume42
Issue number2
DOIs
StatePublished - Aug 1 2012

Keywords

  • Aortic valve-sparing operation
  • Outcome
  • Reimplantation

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'The outcome after aortic valve-sparing (David) operation in 179 patients: A single-centre experience'. Together they form a unique fingerprint.

  • Cite this

    Leontyev, S., Trommer, C., Subramanian, S., Lehmann, S., Dmitrieva, Y., Misfeld, M., Mohr, F. W., & Borger, M. A. (2012). The outcome after aortic valve-sparing (David) operation in 179 patients: A single-centre experience. European Journal of Cardio-thoracic Surgery, 42(2), 261-267. [ezs011]. https://doi.org/10.1093/ejcts/ezs011