The pathophysiology of cardiovascular disease and diabetes: Beyond blood pressure and lipids

Research output: Contribution to journalReview article

109 Scopus citations

Abstract

The pathophysiology of the link between diabetes and cardiovascular disease (CVD) is complex and multifactorial. Understanding these profound mechanisms of disease can help clinicians identify and treat CVD in patients with diabetes, as well as help patients prevent these potentially devastating complications. This article reviews the biological basis of the link between diabetes and CVD, from defects in the vasculature to the cellular and molecular mechanisms specific to insulin-resistant states and hyperglycemia. It concludes with a discussion of heart failure in diabetes, a clinical entity that demonstrates many of the mechanisms discussed.

Original languageEnglish (US)
Pages (from-to)160-165
Number of pages6
JournalDiabetes Spectrum
Volume21
Issue number3
DOIs
StatePublished - Jun 1 2008

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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