The perfect storm

Torsades de Pointes in a child with leukemia

Rochelle Bagatell, Michael Hainstock, Merlin C. Lowe, Brent J. Barber, Ricardo A Samson

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Torsades de Pointes (TdP) is a life-threatening ventricular arrhythmia that can be associated with metabolic abnormalities, exposure to arrhythmogenic medications, and congenital long-QT syndrome. This report describes a patient with ALL and multiple complications of therapy who developed TdP. The patient had no evidence of congenital long-QT syndrome, but a constellation of factors appears to have led to QT prolongation, ventricular ectopy, and TdP. Although the patient suffered cardiac arrest, rapid recognition of TdP and prompt defibrillation resulted in an excellent outcome.

Original languageEnglish (US)
Pages (from-to)996-999
Number of pages4
JournalPediatric Blood and Cancer
Volume49
Issue number7
DOIs
StatePublished - Dec 2007

Fingerprint

Torsades de Pointes
Leukemia
Long QT Syndrome
Heart Arrest
Cardiac Arrhythmias
Therapeutics

Keywords

  • Acute lymphocytic leukemia
  • Cardiac arrest
  • Torsades de Pointes
  • Ventricular arrhythmia

ASJC Scopus subject areas

  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

The perfect storm : Torsades de Pointes in a child with leukemia. / Bagatell, Rochelle; Hainstock, Michael; Lowe, Merlin C.; Barber, Brent J.; Samson, Ricardo A.

In: Pediatric Blood and Cancer, Vol. 49, No. 7, 12.2007, p. 996-999.

Research output: Contribution to journalArticle

Bagatell, Rochelle ; Hainstock, Michael ; Lowe, Merlin C. ; Barber, Brent J. ; Samson, Ricardo A. / The perfect storm : Torsades de Pointes in a child with leukemia. In: Pediatric Blood and Cancer. 2007 ; Vol. 49, No. 7. pp. 996-999.
@article{0c8f44100c184825b8555d22e7578616,
title = "The perfect storm: Torsades de Pointes in a child with leukemia",
abstract = "Torsades de Pointes (TdP) is a life-threatening ventricular arrhythmia that can be associated with metabolic abnormalities, exposure to arrhythmogenic medications, and congenital long-QT syndrome. This report describes a patient with ALL and multiple complications of therapy who developed TdP. The patient had no evidence of congenital long-QT syndrome, but a constellation of factors appears to have led to QT prolongation, ventricular ectopy, and TdP. Although the patient suffered cardiac arrest, rapid recognition of TdP and prompt defibrillation resulted in an excellent outcome.",
keywords = "Acute lymphocytic leukemia, Cardiac arrest, Torsades de Pointes, Ventricular arrhythmia",
author = "Rochelle Bagatell and Michael Hainstock and Lowe, {Merlin C.} and Barber, {Brent J.} and Samson, {Ricardo A}",
year = "2007",
month = "12",
doi = "10.1002/pbc.20712",
language = "English (US)",
volume = "49",
pages = "996--999",
journal = "Pediatric Blood and Cancer",
issn = "1545-5009",
publisher = "Wiley-Liss Inc.",
number = "7",

}

TY - JOUR

T1 - The perfect storm

T2 - Torsades de Pointes in a child with leukemia

AU - Bagatell, Rochelle

AU - Hainstock, Michael

AU - Lowe, Merlin C.

AU - Barber, Brent J.

AU - Samson, Ricardo A

PY - 2007/12

Y1 - 2007/12

N2 - Torsades de Pointes (TdP) is a life-threatening ventricular arrhythmia that can be associated with metabolic abnormalities, exposure to arrhythmogenic medications, and congenital long-QT syndrome. This report describes a patient with ALL and multiple complications of therapy who developed TdP. The patient had no evidence of congenital long-QT syndrome, but a constellation of factors appears to have led to QT prolongation, ventricular ectopy, and TdP. Although the patient suffered cardiac arrest, rapid recognition of TdP and prompt defibrillation resulted in an excellent outcome.

AB - Torsades de Pointes (TdP) is a life-threatening ventricular arrhythmia that can be associated with metabolic abnormalities, exposure to arrhythmogenic medications, and congenital long-QT syndrome. This report describes a patient with ALL and multiple complications of therapy who developed TdP. The patient had no evidence of congenital long-QT syndrome, but a constellation of factors appears to have led to QT prolongation, ventricular ectopy, and TdP. Although the patient suffered cardiac arrest, rapid recognition of TdP and prompt defibrillation resulted in an excellent outcome.

KW - Acute lymphocytic leukemia

KW - Cardiac arrest

KW - Torsades de Pointes

KW - Ventricular arrhythmia

UR - http://www.scopus.com/inward/record.url?scp=35648947256&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35648947256&partnerID=8YFLogxK

U2 - 10.1002/pbc.20712

DO - 10.1002/pbc.20712

M3 - Article

VL - 49

SP - 996

EP - 999

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

SN - 1545-5009

IS - 7

ER -