The peripheral myelin protein 22 kDa (PMP22) gene is amplified in cell lines derived from glioma and osteogenic sarcoma: A new candidate for an oncogene?

T. Liehr, O. Park, B. G. Feuerstein, E. Gebhart, B. Rautenstrauss

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Two glioma (SF188, SF763) and two osteogenic sarcoma cell lines (RH30, SA1) were examined for the presence of an amplification of the PMP22 gene by means of fluorescence in situ hybridization (FISH). In one cell line of both cell types, we found about 10 copies of the PMP22 (peripheral myelin protein 22 kDa) gene, located on different marker chromosomes within homogeneously staining regions. Surrounding chromosome 17p material was found to be coamplified, but coamplification of TP53 (17p13) and erbB2/Her2 (17q11.12) were excluded by FISH for both cell lines, SF763 and RH30. This is the first report of a PMP22 amplification in cell lines derived from human tumors.

Original languageEnglish (US)
Pages (from-to)915-919
Number of pages5
JournalInternational journal of oncology
Volume10
Issue number5
StatePublished - May 29 1997
Externally publishedYes

Keywords

  • FISH
  • PMP22
  • amplification
  • glioma
  • oncogene
  • osteogenic sarcoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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