Clonal rearrangements of the bcl- and b<l-2 protoonco-genes are found in many B-lineage non-Hodgkin s lymphomas (NHL) and may play a role in their pathogenesis. We investigated rearrangements of the hcl-\ and bt7-2 protooncogenes in 13 cases of B lineage diffuse small cleaved-cell lymphoma (DSCL), and correlated the results with clinical history, immunophenotype, and outcome. Six cases showed bcl-2 rearrangements, including four patients with an antecedent follicular small cleaved-cell lymphoma (FSCL). Two patients had a bcl-\ rearrangement, including one with a previous FSCL. Of the five patients who lacked detectable bcl-\ or bcl-2 rearrangements, one had an FSCL history. Similar to the lack of correlation between clinical history and genotype, there was no correlation between genotype and immunophenotype. Our results indicate that although DSCL is a morphologically uniform disease, different molecular genetic pathways are involved in its genesis. Follow-up showed four of the six DSCL patients with bcl-2 rearrangements were alive with a median survival of 56 months, whereas the median survival of the seven patients lacking a bcl-2 rearrangement was 17 months and included only one survivor. Thus bcl-2 rearrangements in DSCL may define a patient subset with a more indolent genetic abnormality and prolonged survival.
|Original language||English (US)|
|Number of pages||6|
|Journal||Diagnostic Molecular Pathology|
|State||Published - 1994|
- B-cell lymphoma
- Diffuse small cleavedcell lymphoma
ASJC Scopus subject areas
- Cell Biology
- Molecular Biology
- Pathology and Forensic Medicine
The presence of bcl-l and bci-2 gene rearrangements in diffuse small cleaved-cell lymphoma. / Leith, Catherine P.; Willman, Cheryi L.; Perry, Catherine S; Miller, Thomas P; Grogan, Thomas M.In: Diagnostic Molecular Pathology, Vol. 3, No. 3, 1994, p. 178-183.
Research output: Contribution to journal › Article
TY - JOUR
T1 - The presence of bcl-l and bci-2 gene rearrangements in diffuse small cleaved-cell lymphoma
AU - Leith, Catherine P.
AU - Willman, Cheryi L.
AU - Perry, Catherine S
AU - Miller, Thomas P
AU - Grogan, Thomas M.
PY - 1994
Y1 - 1994
N2 - Clonal rearrangements of the bcl- and b
AB - Clonal rearrangements of the bcl- and b
KW - B-cell lymphoma
KW - Bcl-1
KW - Bcl-2
KW - Diffuse small cleavedcell lymphoma
UR - http://www.scopus.com/inward/record.url?scp=0028031023&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028031023&partnerID=8YFLogxK
M3 - Article
C2 - 7981893
AN - SCOPUS:0028031023
VL - 3
SP - 178
EP - 183
JO - Diagnostic Molecular Pathology
JF - Diagnostic Molecular Pathology
SN - 1052-9551
IS - 3