The prevalence of pulmonary embolism and pulmonary hypertension in patients with type II diabetes mellitus

Mohammad R Movahed, Mehrtash Hashemzadeh, M. Mazen Jamal

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Background: Patients with diabetes mellitus (DM) have a hypercoagulable state that may increase their risk for thromboembolism. However, the data about this association are contradictory in the literature. The goal of this study was to evaluate the occurrence of pulmonary embolism (PE) and pulmonary hypertension (PHT) in patients with DM after adjusting for coronary artery disease (CAD), congestive heart failure (CHF), hypertension, and smoking using a large database. Method: We used patient treatment file documents to inpatient hospital admissions containing discharge diagnoses (International Classification of Diseases, Ninth Revision, Clinical Modification [ICD-9-CM] codes) from Veterans Health Administration Hospitals. The patients were classified into two groups: a DM group with an ICD-9-CM code for DM (293,124), and a control group with an ICD-9-CM code for hypertension but no DM (552,623). The ICD-9-CM code for PE (415.19) and the ICD-9-CM code for PHT (416.0) were used to study prevalence of these diseases in DM patients vs control patients. We performed univariate and multivariate analyses adjusting for CAD, CHF, and smoking. Continuous variables were analyzed by unpaired t test. Binary variables were analyzed by χ2 and Fisher exact tests. Results: PE was present in 2,011 patients with DM (0.7%) vs 2,759 patients (0.5%) in the control group. PHT was present in 3,356 patients with DM (1.1%) vs 3,357 patients (0.6%) in the control group. Using multivariate analysis, DM remained independently associated with PE (odds ratio [OR], 1.27; 95% confidence interval [CI], 1.19 to 1.35; p < 0.001) and with PHT (OR, 1.53; 95% CI, 1.45 to 1.60; p < 0.001). Conclusion: Patients with DM have significantly higher prevalence of PE and PHT independent of CAD, hypertension, CHF, or smoking. The pathogenesis of this association is not known at this time.

Original languageEnglish (US)
Pages (from-to)3568-3571
Number of pages4
JournalChest
Volume128
Issue number5
DOIs
StatePublished - Nov 2005
Externally publishedYes

Fingerprint

Pulmonary Embolism
Pulmonary Hypertension
Type 2 Diabetes Mellitus
Diabetes Mellitus
International Classification of Diseases
Coronary Artery Disease
Heart Failure
Smoking
Hypertension
Control Groups
Multivariate Analysis
Odds Ratio
Confidence Intervals
Veterans Health
United States Department of Veterans Affairs
Thromboembolism
Inpatients
Cross-Sectional Studies
Databases

Keywords

  • Deep vein thrombosis
  • Diabetes mellitus
  • Pulmonary embolism
  • Pulmonary hypertension
  • Sudden death

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

The prevalence of pulmonary embolism and pulmonary hypertension in patients with type II diabetes mellitus. / Movahed, Mohammad R; Hashemzadeh, Mehrtash; Jamal, M. Mazen.

In: Chest, Vol. 128, No. 5, 11.2005, p. 3568-3571.

Research output: Contribution to journalArticle

Movahed, Mohammad R ; Hashemzadeh, Mehrtash ; Jamal, M. Mazen. / The prevalence of pulmonary embolism and pulmonary hypertension in patients with type II diabetes mellitus. In: Chest. 2005 ; Vol. 128, No. 5. pp. 3568-3571.
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abstract = "Background: Patients with diabetes mellitus (DM) have a hypercoagulable state that may increase their risk for thromboembolism. However, the data about this association are contradictory in the literature. The goal of this study was to evaluate the occurrence of pulmonary embolism (PE) and pulmonary hypertension (PHT) in patients with DM after adjusting for coronary artery disease (CAD), congestive heart failure (CHF), hypertension, and smoking using a large database. Method: We used patient treatment file documents to inpatient hospital admissions containing discharge diagnoses (International Classification of Diseases, Ninth Revision, Clinical Modification [ICD-9-CM] codes) from Veterans Health Administration Hospitals. The patients were classified into two groups: a DM group with an ICD-9-CM code for DM (293,124), and a control group with an ICD-9-CM code for hypertension but no DM (552,623). The ICD-9-CM code for PE (415.19) and the ICD-9-CM code for PHT (416.0) were used to study prevalence of these diseases in DM patients vs control patients. We performed univariate and multivariate analyses adjusting for CAD, CHF, and smoking. Continuous variables were analyzed by unpaired t test. Binary variables were analyzed by χ2 and Fisher exact tests. Results: PE was present in 2,011 patients with DM (0.7{\%}) vs 2,759 patients (0.5{\%}) in the control group. PHT was present in 3,356 patients with DM (1.1{\%}) vs 3,357 patients (0.6{\%}) in the control group. Using multivariate analysis, DM remained independently associated with PE (odds ratio [OR], 1.27; 95{\%} confidence interval [CI], 1.19 to 1.35; p < 0.001) and with PHT (OR, 1.53; 95{\%} CI, 1.45 to 1.60; p < 0.001). Conclusion: Patients with DM have significantly higher prevalence of PE and PHT independent of CAD, hypertension, CHF, or smoking. The pathogenesis of this association is not known at this time.",
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N2 - Background: Patients with diabetes mellitus (DM) have a hypercoagulable state that may increase their risk for thromboembolism. However, the data about this association are contradictory in the literature. The goal of this study was to evaluate the occurrence of pulmonary embolism (PE) and pulmonary hypertension (PHT) in patients with DM after adjusting for coronary artery disease (CAD), congestive heart failure (CHF), hypertension, and smoking using a large database. Method: We used patient treatment file documents to inpatient hospital admissions containing discharge diagnoses (International Classification of Diseases, Ninth Revision, Clinical Modification [ICD-9-CM] codes) from Veterans Health Administration Hospitals. The patients were classified into two groups: a DM group with an ICD-9-CM code for DM (293,124), and a control group with an ICD-9-CM code for hypertension but no DM (552,623). The ICD-9-CM code for PE (415.19) and the ICD-9-CM code for PHT (416.0) were used to study prevalence of these diseases in DM patients vs control patients. We performed univariate and multivariate analyses adjusting for CAD, CHF, and smoking. Continuous variables were analyzed by unpaired t test. Binary variables were analyzed by χ2 and Fisher exact tests. Results: PE was present in 2,011 patients with DM (0.7%) vs 2,759 patients (0.5%) in the control group. PHT was present in 3,356 patients with DM (1.1%) vs 3,357 patients (0.6%) in the control group. Using multivariate analysis, DM remained independently associated with PE (odds ratio [OR], 1.27; 95% confidence interval [CI], 1.19 to 1.35; p < 0.001) and with PHT (OR, 1.53; 95% CI, 1.45 to 1.60; p < 0.001). Conclusion: Patients with DM have significantly higher prevalence of PE and PHT independent of CAD, hypertension, CHF, or smoking. The pathogenesis of this association is not known at this time.

AB - Background: Patients with diabetes mellitus (DM) have a hypercoagulable state that may increase their risk for thromboembolism. However, the data about this association are contradictory in the literature. The goal of this study was to evaluate the occurrence of pulmonary embolism (PE) and pulmonary hypertension (PHT) in patients with DM after adjusting for coronary artery disease (CAD), congestive heart failure (CHF), hypertension, and smoking using a large database. Method: We used patient treatment file documents to inpatient hospital admissions containing discharge diagnoses (International Classification of Diseases, Ninth Revision, Clinical Modification [ICD-9-CM] codes) from Veterans Health Administration Hospitals. The patients were classified into two groups: a DM group with an ICD-9-CM code for DM (293,124), and a control group with an ICD-9-CM code for hypertension but no DM (552,623). The ICD-9-CM code for PE (415.19) and the ICD-9-CM code for PHT (416.0) were used to study prevalence of these diseases in DM patients vs control patients. We performed univariate and multivariate analyses adjusting for CAD, CHF, and smoking. Continuous variables were analyzed by unpaired t test. Binary variables were analyzed by χ2 and Fisher exact tests. Results: PE was present in 2,011 patients with DM (0.7%) vs 2,759 patients (0.5%) in the control group. PHT was present in 3,356 patients with DM (1.1%) vs 3,357 patients (0.6%) in the control group. Using multivariate analysis, DM remained independently associated with PE (odds ratio [OR], 1.27; 95% confidence interval [CI], 1.19 to 1.35; p < 0.001) and with PHT (OR, 1.53; 95% CI, 1.45 to 1.60; p < 0.001). Conclusion: Patients with DM have significantly higher prevalence of PE and PHT independent of CAD, hypertension, CHF, or smoking. The pathogenesis of this association is not known at this time.

KW - Deep vein thrombosis

KW - Diabetes mellitus

KW - Pulmonary embolism

KW - Pulmonary hypertension

KW - Sudden death

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