The Psychotropic Effects of Vagus Nerve Stimulation in Epilepsy

Eric J. Foltz, David M Labiner

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

There is a better understanding of comorbid conditions associated with epilepsy, particularly psychiatric disorders that have led to new treatment strategies. Based on similar sites and mechanisms of action, as well as effects on mood noted in the treatment of epilepsy, several antiepileptic medications have subsequently been studied for use in the treatment of psychiatric conditions. Carbamazapine, valproic acid, and lamotrigine, among others, have been used in the treatment of bipolar disorder. These agents have also been used as adjunctive treatment for depression. Vagus nerve has been briefly explained; it contains approximately 80% afferent fibers and 20% efferent fibers. Sensory information from the head, neck, thorax, and abdomen is carried to the nucleus of the solitary tract (NTS). From the NTS, there are bilateral projections to several areas in the brain, including the cerebellum, the periaqueductal gray, the raphe nucleus, the locus coeruleus, the limbic system, and the cerebral cortex. Thus, the Vagus nerve has a potential role in regulating seizure activity, emotion, mood, and pain.

Original languageEnglish (US)
Title of host publicationPsychiatric Controversies in Epilepsy
PublisherElsevier Inc.
Pages283-295
Number of pages13
ISBN (Print)9780123740069
DOIs
StatePublished - 2008

Fingerprint

Vagus Nerve Stimulation
Epilepsy
Vagus Nerve
Psychiatry
Therapeutics
Limbic System
Periaqueductal Gray
Solitary Nucleus
Raphe Nuclei
Locus Coeruleus
Valproic Acid
Bipolar Disorder
Cerebral Cortex
Abdomen
Anticonvulsants
Cerebellum
Emotions
Seizures
Neck
Thorax

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Foltz, E. J., & Labiner, D. M. (2008). The Psychotropic Effects of Vagus Nerve Stimulation in Epilepsy. In Psychiatric Controversies in Epilepsy (pp. 283-295). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374006-9.00019-9

The Psychotropic Effects of Vagus Nerve Stimulation in Epilepsy. / Foltz, Eric J.; Labiner, David M.

Psychiatric Controversies in Epilepsy. Elsevier Inc., 2008. p. 283-295.

Research output: Chapter in Book/Report/Conference proceedingChapter

Foltz, EJ & Labiner, DM 2008, The Psychotropic Effects of Vagus Nerve Stimulation in Epilepsy. in Psychiatric Controversies in Epilepsy. Elsevier Inc., pp. 283-295. https://doi.org/10.1016/B978-0-12-374006-9.00019-9
Foltz EJ, Labiner DM. The Psychotropic Effects of Vagus Nerve Stimulation in Epilepsy. In Psychiatric Controversies in Epilepsy. Elsevier Inc. 2008. p. 283-295 https://doi.org/10.1016/B978-0-12-374006-9.00019-9
Foltz, Eric J. ; Labiner, David M. / The Psychotropic Effects of Vagus Nerve Stimulation in Epilepsy. Psychiatric Controversies in Epilepsy. Elsevier Inc., 2008. pp. 283-295
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