The ratio of human X chromosome to autosome diversity is positively correlated with genetic distance from genes

Michael F Hammer, August E. Woerner, Fernando L. Mendez, Joseph C Watkins, Murray P. Cox, Jeffrey D. Wall

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The ratio of X-linked to autosomal diversity was estimated from an analysis of six human genome sequences and found to deviate from the expected value of 0.75. However, the direction of this deviation depends on whether a particular sequence is close to or far from the nearest gene. This pattern may be explained by stronger locally acting selection on X-linked genes compared with autosomal genes, combined with larger effective population sizes for females than for males.

Original languageEnglish (US)
Pages (from-to)830-831
Number of pages2
JournalNature Genetics
Volume42
Issue number10
DOIs
StatePublished - Oct 2010

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Chromosomes, Human, X
X-Linked Genes
Human Genome
Population Density
Genes

ASJC Scopus subject areas

  • Genetics
  • Medicine(all)

Cite this

The ratio of human X chromosome to autosome diversity is positively correlated with genetic distance from genes. / Hammer, Michael F; Woerner, August E.; Mendez, Fernando L.; Watkins, Joseph C; Cox, Murray P.; Wall, Jeffrey D.

In: Nature Genetics, Vol. 42, No. 10, 10.2010, p. 830-831.

Research output: Contribution to journalArticle

Hammer, Michael F ; Woerner, August E. ; Mendez, Fernando L. ; Watkins, Joseph C ; Cox, Murray P. ; Wall, Jeffrey D. / The ratio of human X chromosome to autosome diversity is positively correlated with genetic distance from genes. In: Nature Genetics. 2010 ; Vol. 42, No. 10. pp. 830-831.
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