The regulation of cell motility and chemotaxis by phospholipid signaling

Verena Kölsch, Pascale G. Charest, Richard A. Firtel

Research output: Contribution to journalArticle

256 Scopus citations

Abstract

Phosphoinositide 3-kinase (P13K), PTEN and localized phosphatidylinositol (3,4,5)-trisphosphate [PtdIns(3,4,5)P3] play key roles in chemotaxis, regulating cell motility by controlling the actin cytoskeleton in Dictyostelium and mammalian cells. PtdIns(3,4,5)P3, produced by PI3K, acts via diverse downstream signaling components, including the GTPase Rac, Arf-GTPases and the kinase Akt (PKB). It has become increasingly apparent, however, that chemotaxis results from an interplay between the P13K-PTEN pathway and other parallel pathways in Dictyostelium and mammalian cells. In Dictyostelium, the phospholipase PLA2 acts in concert with P13K to regulate chemotaxis, whereas phospholipase C (PLC) plays a supporting role in modulating P13K activity. In adenocarcinoma cells, PLC and the actin regulator cofilin seem to provide the direction-sensing machinery, whereas P13K might regulate motility.

Original languageEnglish (US)
Pages (from-to)551-559
Number of pages9
JournalJournal of Cell Science
Volume121
Issue number5
DOIs
StatePublished - Mar 1 2008
Externally publishedYes

Keywords

  • Cytoskeleton
  • Dictyostelium
  • PTEN
  • Phosphatidylinositol (3,4,5)-trisphosphate [PtdIns(3,4,5)P]
  • Phospholipase
  • Ras

ASJC Scopus subject areas

  • Cell Biology

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