The relationship between water vapor absorption and desorption by phospholipids and bilayer phase transitions

Heidi - Mansour, George Zografi

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Water vapor absorption and desorption at 25°C and phase transition temperatures of phospholipid bilayers were measured as a function of relative humidity (RH) to better understand how the patterns of water vapor absorption and desorption are linked to corresponding phase changes induced by the level of hydration. Comparisons were made of the dipalmitoyl and palmitoyloleyol esters of glycerol derivatized with phosphatidyl-choline, -glycerol, -ethanolamine and with phosphatidic acid. The results suggest that the extent of water vapor absorption and desorption at a given RH reflects the combined effects of water-polar group interaction and access of water to the polar region as controlled by intra- and interbilayer molecular packing and intermolecular attractive and repulsive interactions. The results further suggest that the extent of water vapor absorption and desorption over a range of relative humidities reflects the combined effects of the polar group's ability to interact with water, the access that water has to the polar groups as determined by molecular size and various intermolecular and intrabilayer forces of attraction and repulsion, and interbilayer interactions which influence the degree of order/disorder present in the overall solid-state structure. This behavior is also reflected in the changes observed in the various bilayer phase transition temperatures as a function of RH. Analyses of absorption isotherms suggests that after exceeding a critical RH, water initially interacting with these phospholipids most likely forms either stoichiometric or nonstoichiometric crystal hydrates, as with the disaturated derivatives, or hydrated mesophases, as with the gel states of the monounsaturated derivatives.

Original languageEnglish (US)
Pages (from-to)377-396
Number of pages20
JournalJournal of Pharmaceutical Sciences
Volume96
Issue number2
DOIs
StatePublished - Feb 2007
Externally publishedYes

Fingerprint

Phase Transition
Steam
Humidity
Desorption
Phospholipids
Atmospheric humidity
Phase transitions
Water
Transition Temperature
Glycerol
Cold Climate
Derivatives
Phosphatidylglycerols
Phosphatidic Acids
Ethanolamine
Order disorder transitions
Hydrates
Phosphatidylcholines
Hydration
Isotherms

Keywords

  • Bilayer
  • Calorimetry (DSC)
  • Dehydration
  • Hydration
  • Liposomes
  • Physicochemical
  • Solid state
  • Surface chemistry
  • Thermodynamics
  • Water in solids

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science

Cite this

The relationship between water vapor absorption and desorption by phospholipids and bilayer phase transitions. / Mansour, Heidi -; Zografi, George.

In: Journal of Pharmaceutical Sciences, Vol. 96, No. 2, 02.2007, p. 377-396.

Research output: Contribution to journalArticle

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