The relationship of the major murine histocompatibility region associated IA antigens to mitogen responses

John E. Niederhuber, Jeffrey A Frelinger, Elizabeth Dugan, Donald C. Shreffler

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Genes located in the I region of the H-2 complex control a system of lymphocyte alloantigens (Ia) which are expressed on subpopulations of T and B cells. Specific anti-Ia serum plus rabbit complement removed the B-lymphocyte population responsive to the mitogen LPS and the subpopulation of T cells responsive to Con-A. Lymphocytes sensitive to PHA or leucoagglutinin were not removed by anti-Ia serum and complement. Significant inhibition of the proliferative response to LPS was also obtained by brief periods of cell pretreatment with anti-Ia antibodies without complement. This inhibition was specific with the appropriate anti-Ia serum and did not occur with anti-H-2K sera or when cells of a different I region were pretreated.

Original languageEnglish (US)
Pages (from-to)563-570
Number of pages8
JournalJournal of Surgical Research
Volume20
Issue number6
DOIs
StatePublished - 1976
Externally publishedYes

Fingerprint

Histocompatibility
Histocompatibility Antigens Class II
Mitogens
Serum
B-Lymphocytes
Lymphocytes
T-Lymphocytes
Isoantigens
Anti-Idiotypic Antibodies
Rabbits
Population
Genes

ASJC Scopus subject areas

  • Surgery

Cite this

The relationship of the major murine histocompatibility region associated IA antigens to mitogen responses. / Niederhuber, John E.; Frelinger, Jeffrey A; Dugan, Elizabeth; Shreffler, Donald C.

In: Journal of Surgical Research, Vol. 20, No. 6, 1976, p. 563-570.

Research output: Contribution to journalArticle

Niederhuber, John E. ; Frelinger, Jeffrey A ; Dugan, Elizabeth ; Shreffler, Donald C. / The relationship of the major murine histocompatibility region associated IA antigens to mitogen responses. In: Journal of Surgical Research. 1976 ; Vol. 20, No. 6. pp. 563-570.
@article{21df146453ab48239e2b846dd9427194,
title = "The relationship of the major murine histocompatibility region associated IA antigens to mitogen responses",
abstract = "Genes located in the I region of the H-2 complex control a system of lymphocyte alloantigens (Ia) which are expressed on subpopulations of T and B cells. Specific anti-Ia serum plus rabbit complement removed the B-lymphocyte population responsive to the mitogen LPS and the subpopulation of T cells responsive to Con-A. Lymphocytes sensitive to PHA or leucoagglutinin were not removed by anti-Ia serum and complement. Significant inhibition of the proliferative response to LPS was also obtained by brief periods of cell pretreatment with anti-Ia antibodies without complement. This inhibition was specific with the appropriate anti-Ia serum and did not occur with anti-H-2K sera or when cells of a different I region were pretreated.",
author = "Niederhuber, {John E.} and Frelinger, {Jeffrey A} and Elizabeth Dugan and Shreffler, {Donald C.}",
year = "1976",
doi = "10.1016/0022-4804(76)90091-3",
language = "English (US)",
volume = "20",
pages = "563--570",
journal = "Journal of Surgical Research",
issn = "0022-4804",
publisher = "Academic Press Inc.",
number = "6",

}

TY - JOUR

T1 - The relationship of the major murine histocompatibility region associated IA antigens to mitogen responses

AU - Niederhuber, John E.

AU - Frelinger, Jeffrey A

AU - Dugan, Elizabeth

AU - Shreffler, Donald C.

PY - 1976

Y1 - 1976

N2 - Genes located in the I region of the H-2 complex control a system of lymphocyte alloantigens (Ia) which are expressed on subpopulations of T and B cells. Specific anti-Ia serum plus rabbit complement removed the B-lymphocyte population responsive to the mitogen LPS and the subpopulation of T cells responsive to Con-A. Lymphocytes sensitive to PHA or leucoagglutinin were not removed by anti-Ia serum and complement. Significant inhibition of the proliferative response to LPS was also obtained by brief periods of cell pretreatment with anti-Ia antibodies without complement. This inhibition was specific with the appropriate anti-Ia serum and did not occur with anti-H-2K sera or when cells of a different I region were pretreated.

AB - Genes located in the I region of the H-2 complex control a system of lymphocyte alloantigens (Ia) which are expressed on subpopulations of T and B cells. Specific anti-Ia serum plus rabbit complement removed the B-lymphocyte population responsive to the mitogen LPS and the subpopulation of T cells responsive to Con-A. Lymphocytes sensitive to PHA or leucoagglutinin were not removed by anti-Ia serum and complement. Significant inhibition of the proliferative response to LPS was also obtained by brief periods of cell pretreatment with anti-Ia antibodies without complement. This inhibition was specific with the appropriate anti-Ia serum and did not occur with anti-H-2K sera or when cells of a different I region were pretreated.

UR - http://www.scopus.com/inward/record.url?scp=0017186164&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017186164&partnerID=8YFLogxK

U2 - 10.1016/0022-4804(76)90091-3

DO - 10.1016/0022-4804(76)90091-3

M3 - Article

C2 - 59005

AN - SCOPUS:0017186164

VL - 20

SP - 563

EP - 570

JO - Journal of Surgical Research

JF - Journal of Surgical Research

SN - 0022-4804

IS - 6

ER -