The relationship of the major murine histocompatibility region associated IA antigens to mitogen responses

John E. Niederhuber, Jeffrey A. Frelinger, Elizabeth Dugan, Donald C. Shreffler

Research output: Contribution to journalArticle

1 Scopus citations


Genes located in the I region of the H-2 complex control a system of lymphocyte alloantigens (Ia) which are expressed on subpopulations of T and B cells. Specific anti-Ia serum plus rabbit complement removed the B-lymphocyte population responsive to the mitogen LPS and the subpopulation of T cells responsive to Con-A. Lymphocytes sensitive to PHA or leucoagglutinin were not removed by anti-Ia serum and complement. Significant inhibition of the proliferative response to LPS was also obtained by brief periods of cell pretreatment with anti-Ia antibodies without complement. This inhibition was specific with the appropriate anti-Ia serum and did not occur with anti-H-2K sera or when cells of a different I region were pretreated.

Original languageEnglish (US)
Pages (from-to)563-570
Number of pages8
JournalJournal of Surgical Research
Issue number6
StatePublished - Jun 1976
Externally publishedYes


ASJC Scopus subject areas

  • Surgery

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