The relative influence of atomization and evaporation on metered dose inhaler drug delivery efficiency

Stephen W. Stein, Paul B Myrdal

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Factors influencing the delivery efficiency fromHFA-134a MDIs were examined theoretically and experimentally. The time required for evaporation of HFA-134a and ethanol droplets were theoretically calculated. HFA-134a droplets were shown to evaporate approximately seven times faster than ethanol droplets of the same size, even though HFA-134a droplets cool to approximately 78 degrees below ambient temperature during evaporation. MDI delivery efficiency was experimentally shown to decrease with increasing ethanol concentration, however, the corresponding decrease in vapor pressure was not the primary variable responsible for the decreased efficiency. Rather, this was shown to be primarily due to the increased time required for the droplets to evaporate as ethanol concentration increased. Droplets that evaporate slowly remain for a longer period in the size range that is more likely to deposit via turbulent deposition in the actuator mouthpiece or USP Inlet during cascade impaction tests. Tests with experimental MDIs using alternative cosolvents confirmed that MDI delivery efficiency is much more sensitive to the time required for evaporation of the droplets than on the formulation vapor pressure or the size of the atomized droplets. This indicates that factors affecting the evaporation of an MDI aerosol play a larger role in determining MDI delivery efficiency than do atomization effects.

Original languageEnglish (US)
Pages (from-to)335-347
Number of pages13
JournalAerosol Science and Technology
Volume40
Issue number5
DOIs
StatePublished - May 2006

Fingerprint

Atomization
Drug delivery
HFA 134a
droplet
Evaporation
drug
evaporation
ethanol
Ethanol
Vapor pressure
vapor pressure
dose
Aerosols
range size
Actuators
Deposits
aerosol

ASJC Scopus subject areas

  • Materials Science(all)
  • Environmental Chemistry
  • Pollution

Cite this

The relative influence of atomization and evaporation on metered dose inhaler drug delivery efficiency. / Stein, Stephen W.; Myrdal, Paul B.

In: Aerosol Science and Technology, Vol. 40, No. 5, 05.2006, p. 335-347.

Research output: Contribution to journalArticle

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