The Risk of Cancer and Serum Vitamin A and E and Carotenoids

Frank L. Meyskens, Thomas E. Moon, David S. Alberts, Cheryl Ritenbaugh, Robert S. London, Marguerite Stevens, John A. Baron, Walter Willett, B. Frank Polk, Barbara A. Underwood

Research output: Contribution to journalLetterpeer-review

1 Scopus citations


To the Editor: We do not disagree with the conclusions of Willett et al., based on their excellent study (Feb. 16 issue)1; however, we think that alternative explanations should be considered along with the additional investigations reported in the literature that support the role of vitamin A and beta-carotene associated wilh lower incidences of certain cancers.2,3 Although serum retinol concentrations are tightly regulated within a narrow range, few data exist concerning related tissue concentrations of retinol and the retinyl esters, which probably play an important part as natural inhibitors of carcinogenesis. The administration of intermediate or high doses of.

Original languageEnglish (US)
Pages (from-to)121-123
Number of pages3
JournalNew England Journal of Medicine
Issue number2
StatePublished - Jul 12 1984

ASJC Scopus subject areas

  • Medicine(all)


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